4-((4-fluorophenyl)thio)quinolone

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4-((4-fluorophenyl)thio)quinolone
• 英文别名: 4-((4-fluorophenyl)thio)quinoline；4-(4-Fluorophenyl)sulfanylquinoline
• 化学式: C₁₅H₁₀FNS
• 分子量: 255.316
• InChiKey: VDGWPFTVEVLLBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-((4-fluorophenyl)thio)quinolone 在 oxone||potassium monopersulfate triple salt 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 12.0h， 以47%的产率得到4-((4-fluorophenyl)sulfinyl)quinoline
  参考文献：
  名称：

  KR2020/83134

  摘要：

  公开号：
• 作为产物：
  描述：

  4-氯喹啉 、 对氟苯硫酚 以 乙醇 为溶剂， 以47.4 %的产率得到4-((4-fluorophenyl)thio)quinolone
  参考文献：
  名称：

  Novel Isoquinoline Derivative, Preparing Method Thereof, and Pharmaceutical Composition for Preventing or Treating Autophagy Related Diseases Containing the Same as an Active Ingredient

  摘要：

  The present invention relates to a novel isoquinoline derivative, a preparing method thereof, and a pharmaceutical composition for preventing or treating autophagy related diseases containing the same as an active ingredient. The novel isoquinoline furanone derivative according to the present invention is capable of regulating autophagy activity, and thus, by using this derivative as an active ingredient, there is a useful effect that can be used as a pharmaceutical composition for preventing or treating autophagy-related diseases such as neurodegenerative diseases, cancer, metabolic diseases, inflammatory diseases or melanogenesis-related diseases, a health functional food composition for ameliorating thereof, or a cosmetic composition with a whitening function.

  公开号：

  US20230025531A1

文献信息

• KR2020/83134
  申请人：——

  公开号：——

  公开（公告）日：——
• Novel Isoquinoline Derivative, Preparing Method Thereof, and Pharmaceutical Composition for Preventing or Treating Autophagy Related Diseases Containing the Same as an Active Ingredient
  申请人：Korea Research Institute of Chemical Technology

  公开号：US20230025531A1

  公开（公告）日：2023-01-26

  The present invention relates to a novel isoquinoline derivative, a preparing method thereof, and a pharmaceutical composition for preventing or treating autophagy related diseases containing the same as an active ingredient. The novel isoquinoline furanone derivative according to the present invention is capable of regulating autophagy activity, and thus, by using this derivative as an active ingredient, there is a useful effect that can be used as a pharmaceutical composition for preventing or treating autophagy-related diseases such as neurodegenerative diseases, cancer, metabolic diseases, inflammatory diseases or melanogenesis-related diseases, a health functional food composition for ameliorating thereof, or a cosmetic composition with a whitening function.