p-toluenesulfonylmethyl isocyanide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-toluenesulfonylmethyl isocyanide
• 英文别名: 1-((isocyanomethyl)sulfonyl)-4-methylbenzene；p-tosylmethyl isocyanide；tosylmethyl isocyanide；1-isocyanomethanesulfonyl-4-methyl-benzene
• 化学式: C₉H₁₀NO₂S
• 分子量: 196.25
• InChiKey: YSLRQMSHWBDRRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  p-toluenesulfonylmethyl isocyanide 在 盐酸 、 sodium hydride 作用下， 以 甲醇 、 二甲基亚砜 、 mineral oil 为溶剂， 反应 36.5h， 生成 1,5-双(4-甲基苯基)戊烷-3-酮
  参考文献：
  名称：

  IONIZABLE LIPIDS AND LIPID NANOPARTICLE COMPOSITIONS FOR THE DELIVERY OF NUCLEIC ACIDS

  摘要：

  Novel ionizable lipids are provided. Also provided are novel lipid nanoparticle compositions for the delivery of nucleic acid material to cells in vitro and in vivo with different and improved pharmacokinetic profiles as compared to what is typically observed in the art. Also provided are methods for using the compositions in research and as therapeutics.

  公开号：

  WO2024107906A2

文献信息

• Tandem cycloaddition–decarboxylation of α-keto acid and isocyanide under oxidant-free conditions towards monosubstituted oxazoles
  作者：Ling-Juan Zhang、Mei-Chen Xu、Jie Liu、Xian-Ming Zhang

  DOI：10.1039/c6ra16031j

  日期：——

  An efficient method, tandem [3 + 2] cycloaddition–decarboxylation of α-keto acid and isocyanide promoted by copper salt, has been developed. Under oxidant-free conditions, a series monosubstituted oxazoles have been constructed. Different from the traditional application of α-oxo acids as acyl surrogates, the elegant approach herein ingeniously avoids consuming excess oxidants.

  已经开发出一种有效的方法，即铜盐促进的α-酮酸和异氰酸酯的串联[3 + 2]环加成-脱羧反应。在无氧化剂的条件下，已经构建了一系列单取代的恶唑。与传统的α-氧代酸作为酰基替代物的应用不同，本文的优雅方法巧妙地避免了消耗过量的氧化剂。
• [EN] LIGHT EMITTING MATERIALS FOR ELECTRONICS<br/>[FR] MATÉRIAUX ÉLECTROLUMINESCENTS POUR APPLICATIONS ÉLECTRONIQUES
  申请人：SOLVAY

  公开号：WO2012019948A1

  公开（公告）日：2012-02-16

  The present invention relates to an organometallic complex, to the preparation of said material, to the use of said material and to a light emitting device which transform electric energy into light. The present invention is further related to provide phosphorescent complexes which contribute to extend the life time in operation of said OLEDs and especially when they are involved in the EL. The objectives of this invention are accomplished by iridium complex comprising 7-membered fused ring ligands which are tris-homoleptic or bis-homoleptic with an ancillary ligand.

  本发明涉及一种有机金属配合物，涉及该材料的制备，涉及该材料的使用以及将电能转化为光的发光装置。本发明进一步涉及提供磷光配合物，有助于延长所述OLEDs的运行寿命，特别是当它们参与EL时。该发明的目标通过含有由7个成员的融合环配体组成的铱配合物实现，这些配体是三取代同配体或二取代同配体，同时带有一个辅助配体。
• [EN] NEW CCR2 ANTAGONISTS<br/>[FR] NOUVEAUX ANTAGONISTES DU CCR2
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2011151251A1

  公开（公告）日：2011-12-08

  The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) of formula (Ia) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD.

  本发明涉及一种新的CCR2（CC趋化因子受体2）拮抗剂，其化学式为（Ia），并且它们的用途是提供治疗疾病的药物，特别是肺部疾病，如哮喘和慢性阻塞性肺疾病。
• [EN] PIPERIDINE DERIVATIVES AS NK1 ANTAGONISTS<br/>[FR] ANTAGONISTES DE NK1
  申请人：SCHERING CORP

  公开号：WO2006007540A3

  公开（公告）日：2006-04-13
• 2,5-Bis-(butylsulfanyl)-2,3-dihydro-4H-pyran-2-carbaldehyde in the synthesis of five-membered heterocycles
  作者：Ekaterina A. Verochkina、Victoria G. Fedoseeva、Ludmila I. Larina、Nadezhda V. Vchislo

  DOI：10.24820/ark.5550190.p011.977

  日期：——