N-hydroxy-2-methylbenzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-hydroxy-2-methylbenzenesulfonamide
• 化学式: C₇H₉NO₃S
• 分子量: 187.219
• InChiKey: YOJXSTAWCMFOHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  74.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-hydroxy-2-methylbenzenesulfonamide 在 碘 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以78%的产率得到S-(o-tolyl) 2-methylbenzenesulfonothioate
  参考文献：
  名称：

  Blue Light-Induced Coupling of N-Hydroxy Sulfonamides: An Efficient and Green Approach to Symmetrical Thiosulfonates

  摘要：

  DOI：

  10.1134/s1070428022060136
• 作为产物：
  描述：

  邻甲苯磺酰氯 在 盐酸羟胺 、 magnesium oxide 作用下， 以 甲醇 、 水 为溶剂， 反应 2.0h， 以74%的产率得到N-hydroxy-2-methylbenzenesulfonamide
  参考文献：
  名称：

  A Straightforward Route to Piloty’s Acid Derivatives: A Class of Potential Nitroxyl-Generating Prodrugs

  摘要：

  一系列Piloty的酸衍生物在温和且中性的条件下容易制备。最终产物易于分离，提供了显著优于知名工艺的优势。这种方法特别有吸引力，因为它能干净利落地提供低分子量的脂肪族磺酰羟肟酸，这些化合物因其生理条件下产生HNO的倾向而具有很大的研究价值。

  DOI：

  10.1055/s-0029-1217565

文献信息

• [EN] TRICYCLIC PESTICIDAL COMPOUNDS<br/>[FR] COMPOSÉS PESTICIDES TRICYCLIQUES
  申请人：BASF SE

  公开号：WO2021209265A1

  公开（公告）日：2021-10-21

  The invention relates to compounds of formula (I), wherein the variables are as defined in the specification. It also relates to the use of compounds of formula (I) as an agrochemical pesticide; to pesticidal mixtures comprising compounds of formula (I); and to agrochemical or veterinary compositions comprising compounds of formula (I). Other objects are seed comprising compounds of formula (I); and methods for controlling invertebrate pests, infestation, or infection by invertebrate pests by application of compounds of formula (I).

  该发明涉及公式（I）的化合物，其中变量如规范中定义。它还涉及将公式（I）的化合物用作农药杀虫剂；包含公式（I）化合物的杀虫混合物；以及包含公式（I）化合物的农药或兽药组合物。其他目标是包含公式（I）化合物的种子；以及通过应用公式（I）化合物来控制无脊椎动物害虫、侵害或感染的方法。
• New amino-alkyl-amide derivatives as CCR3 receptor ligands
  申请人：PAPPNE BEHR Agnes

  公开号：US20080287434A1

  公开（公告）日：2008-11-20

  The invention relates to a compound of the general formula (I), as defined herein which is useful for the treatment of a pathology in a patient wherein a CCR3 receptor plays a role in the development of the pathology, and pharmaceutical preparations containing such compound. The invention is also directed to a process for preparing the compound of the general formula (I), and intermediate useful in the preparation.

  本发明涉及一种通式（I）所定义的化合物，其对治疗患者中CCR3受体在病理发展中发挥作用的疾病有用，并且包含这种化合物的制药制剂。本发明还涉及一种制备通式（I）所定义的化合物的方法，以及在制备中有用的中间体。
• Chiral Cp^xRhodium(III)‐Catalyzed Enantioselective Aziridination of Unactivated Terminal Alkenes
  作者：Juanjuan Wang、Mu‐Peng Luo、Yi‐Jie Gu、Yu‐Ying Liu、Qin Yin、Shou‐Guo Wang

  DOI：10.1002/anie.202400502

  日期：2024.3.18

  A chiral cyclopentadienyl-rhodium(III) catalyzed highly enantioselective aziridination of challenging unactivated terminal alkenes and N-pivalolyloxy sulfonamides has been developed. This catalytic system demonstrated outstanding catalytic activity and broad functional group tolerance, yielding synthetically important and highly valuable chiral aziridines with good to excellent yields and enantioselectivities

  开发了一种手性环戊二烯基铑 (III) 催化的具有挑战性的未活化末端烯烃和N-新戊酰氧基磺酰胺的高度对映选择性氮丙啶化反应。该催化体系表现出出色的催化活性和广泛的官能团耐受性，产生具有合成重要性和高价值的手性氮丙啶，具有良好至优异的产率和对映选择性（高达 99% 的产率，93% ee）。
• N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS
  申请人：The Johns Hopkins University

  公开号：EP3124471A1

  公开（公告）日：2017-02-01

  The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.

  本发明涉及N-羟基磺酰胺衍生物，该衍生物可在生理条件下捐献硝酰（HNO），并可用于治疗和/或预防对硝酰治疗有反应的疾病或病症的发生和/或发展，包括心力衰竭和缺血/再灌注损伤。新型 N- 羟基磺酰胺衍生物可在生理条件下以可控速率释放 NHO，HNO 释放速率可通过改变 N- 羟基磺酰胺衍生物上官能团的性质和位置来调节。
• N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
  申请人：Cardioxyl Pharmaceuticals, Inc.

  公开号：US10179765B2

  公开（公告）日：2019-01-15

  The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release HNO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.

  本发明涉及N-羟基磺酰胺衍生物，该衍生物在生理条件下捐献硝基（HNO），可用于治疗和/或预防对硝基疗法有反应的疾病或病症的发生和/或发展，包括心力衰竭和缺血/再灌注损伤。新型 N- 羟基磺酰胺衍生物在生理条件下以可控速率释放 HNO，HNO 释放速率可通过改变 N- 羟基磺酰胺衍生物上官能团的性质和位置来调节。