γ-benzyl glutamic acid methyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: γ-benzyl glutamic acid methyl ester
• 英文别名: 1-benzyl 5-methyl (2S)-2-aminopentanedioate；1-O-benzyl 5-O-methyl (2S)-2-aminopentanedioate
• 化学式: C₁₃H₁₇NO₄
• 分子量: 251.282
• InChiKey: LGOZCOKMYOMSGF-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  78.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  γ-benzyl glutamic acid methyl ester 、 N-叔丁氧羰基-L-丙氨酸 在 三乙胺 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 氯仿 为溶剂， 反应 12.0h， 以38.1%的产率得到(S)-1-benzyl 5-methyl 2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)pentanedioate
  参考文献：
  名称：

  Tetrapeptide Copper Catalysts Capable Of Oxidizing Hydrocarbons At Room Temperature

  摘要：

  本发明涉及能够在室温下氧化烃的肽铜催化剂。

  公开号：

  US20160060292A1

文献信息

• [EN] RNA VIRUS INHIBITOR COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS INHIBITEURS DE VIRUS À ARN ET LEURS UTILISATIONS
  申请人：UNIV ALBERTA

  公开号：WO2022133588A1

  公开（公告）日：2022-06-30

  The present disclosure provides compounds of formula (I) and methods for inhibiting a virus infection, such as a Baltimore Group IV RNA virus infection, such as rhinovirus, coxsackievirus, norovirus and coronavirus. Aspects of the present disclosure also include methods of treating a virus infection in a subject. The human coronavirus can be Severe Acute Respiratory Syndrome coronavirus 2 (SARS-Co V-2), Severe Acute Respiratory syndrome coronavirus 1 (SARS-Co V-l) and Middle Eastern Respiratory syndrome-related coronavirus (MERS- CoV).

  本公开提供式(I)化合物和抑制病毒感染的方法，如巴尔的摩第四组RNA病毒感染，如鼻病毒，柯萨奇病毒，诺如病毒和冠状病毒。本公开还涉及在受试者中治疗病毒感染的方法。人类冠状病毒可以是严重急性呼吸综合症冠状病毒2（SARS-CoV-2），严重急性呼吸综合症冠状病毒1（SARS-CoV-1）和中东呼吸综合症相关冠状病毒（MERS-CoV）。
• PROCESS FOR PREPARING DESMOSINE, ISODESMOSINE, AND DERIVATIVES THEREOF
  申请人：SOPHIA SCHOOL CORPORATION

  公开号：US20150376127A1

  公开（公告）日：2015-12-31

  A process for preparing a compound represented by the following general formula (I) or a salt thereof, which comprises reacting lysine or a protective product thereof or a salt thereof with allysine or a protective product thereof in the presence of a specific trifluoromethane sulfonate to obtain a compound having pyridine ring or a salt thereof. (wherein, in the above-described general formula (I), one of R 1 and R 2 is —CH 2 CH 2 CH 2 CH(NH 2 )COOH group, and the other is hydrogen atom. And wherein, in the above-described general formula (I), one, or two or more of hydrogen atom, one, or two or more of carbon atom, or one, or two or more of nitrogen atom may be substituted with their isotope.)
• US9556119B2
  申请人：——

  公开号：US9556119B2

  公开（公告）日：2017-01-31
• Tetrapeptide Copper Catalysts Capable Of Oxidizing Hydrocarbons At Room Temperature
  申请人：University of the West Indies, a Regional Institution, established by Royal Charter

  公开号：US20160060292A1

  公开（公告）日：2016-03-03

  The present invention relates to peptide copper catalysts capable of oxidizing hydrocarbons at room temperature.

  本发明涉及能够在室温下氧化烃的肽铜催化剂。