4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzaldehyde

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzaldehyde
• 英文别名: 5-(4-Formylbenzylidene)-2,4-thiazolidinedione
• 化学式: C₁₁H₇NO₃S
• 分子量: 233.247
• InChiKey: MYGMULWOOZQJAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  88.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzaldehyde 、 1H-4,5-dihydro-3-(4-chlorophenyl)-5-(2-hydroxyphenyl)pyrazole 以 乙醇 为溶剂， 以90%的产率得到5-{4-[2-(4-chlorophenyl)-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazin-5-yl]benzylidene}-1,3-thiazolidine-2,4-dione
  参考文献：
  名称：

  Synthesis and Biological Activity of Pyrazolo[1,5-c][1,3]benzoxazines Containing a Thiazolidin-4-one Fragment

  摘要：

  5-[4-(2-Aryl-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazin-5-yl)benzylidene]-1,3-thiazolidin-4-ones were synthesized by reactions of 4-[(3-R-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzaldehydes with 2-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)phenols and evaluated for antitumor and anti-inflammatory activities.

  DOI：

  10.1134/s1070428020040053
• 作为产物：
  描述：

  2,4-噻唑烷二酮 、 对苯二甲醛 在 sodium acetate 、 溶剂黄146 作用下， 反应 240.0h， 以71%的产率得到4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzaldehyde
  参考文献：
  名称：

  Synthesis and Biological Activity of Pyrazolo[1,5-c][1,3]benzoxazines Containing a Thiazolidin-4-one Fragment

  摘要：

  5-[4-(2-Aryl-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazin-5-yl)benzylidene]-1,3-thiazolidin-4-ones were synthesized by reactions of 4-[(3-R-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzaldehydes with 2-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)phenols and evaluated for antitumor and anti-inflammatory activities.

  DOI：

  10.1134/s1070428020040053

文献信息

• Quinolines useful in treating cardiovascular disease
  申请人：Collini D. Michael

  公开号：US20050131014A1

  公开（公告）日：2005-06-16

  This invention provides compounds of formula I that are useful in the treatment or inhibition of LXR mediated diseases.

  本发明提供了公式I的化合物，其在治疗或抑制LXR介导的疾病方面是有用的。
• Telomerase inhibitors and methods of their use
  申请人：——

  公开号：US20020120144A1

  公开（公告）日：2002-08-29

  Thiazolidinedione compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are methods for assaying or screening for inhibitors of telomerase activity.

  本发明提供噻唑烷二酮类化合物、组合物和抑制体外端粒酶活性、体外和体内治疗端粒酶介导的疾病或病症的方法。本发明的方法、化合物和组合物可单独使用，也可与其他药理活性剂联合使用，用于治疗由端粒酶活性介导的疾病或病症，例如治疗癌症。本发明还揭示了用于检测或筛选端粒酶活性抑制剂的方法。
• Quinolines and pharmaceutical compositions thereof
  申请人：Wyeth

  公开号：US07576215B2

  公开（公告）日：2009-08-18

  This invention provides compounds of formula I that are useful in the treatment or inhibition of LXR mediated diseases.

  本发明提供了I式化合物，可用于治疗或抑制LXR介导的疾病。
• Synthesis and Biological Activity of Pyrazolo[1,5-c][1,3]benzoxazines Containing a Thiazolidin-4-one Fragment
  作者：V. Y. Horishny、L. Z. Mandzyuk、R. Z. Lytvyn、O. V. Bodnarchuk、V. S. Matiychuk、M. D. Obushak

  DOI：10.1134/s1070428020040053

  日期：2020.4

  5-[4-(2-Aryl-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazin-5-yl)benzylidene]-1,3-thiazolidin-4-ones were synthesized by reactions of 4-[(3-R-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzaldehydes with 2-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)phenols and evaluated for antitumor and anti-inflammatory activities.