2-benzoylamino-N-(4-fluoro-benzenesulfonamido)-5-fluoro-benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-benzoylamino-N-(4-fluoro-benzenesulfonamido)-5-fluoro-benzamide
• 英文别名: N-[4-fluoro-2-[[(4-fluorophenyl)sulfonylamino]carbamoyl]phenyl]benzamide
• 化学式: C₂₀H₁₅F₂N₃O₄S
• 分子量: 431.42
• InChiKey: LFZAFWQYHBFYIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  4-氟苯磺酰肼 、 6-fluoro-2-phenyl-4H-benzo[d][1,3]oxazin-4-one 反应 0.5h， 以99%的产率得到
  参考文献：
  名称：

  Novel parallel synthesis of N-(4-oxo-2-substituted-4H-quinazolin-3-yl)-substituted sulfonamides

  摘要：

  A general method was developed to synthesize a class of N-(4-oxo-2-substituted-4H-quinazolin-3-yl)-substituted sulfonamides in moderate to good yield. This new method can be applied in both single compound and parallel synthesis. About 90 compounds with a variety of substituents were synthesized using this method in a parallel fashion. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.08.183

文献信息

• Novel parallel synthesis of N-(4-oxo-2-substituted-4H-quinazolin-3-yl)-substituted sulfonamides
  作者：Yuefen Zhou、Douglas E. Murphy、Zhongxiang Sun、Vlad E. Gregor

  DOI：10.1016/j.tetlet.2004.08.183

  日期：2004.10

  A general method was developed to synthesize a class of N-(4-oxo-2-substituted-4H-quinazolin-3-yl)-substituted sulfonamides in moderate to good yield. This new method can be applied in both single compound and parallel synthesis. About 90 compounds with a variety of substituents were synthesized using this method in a parallel fashion. (C) 2004 Elsevier Ltd. All rights reserved.