2-(anthracen-2-yl)-4,4-dimethyl-4,5-dihydrooxazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 2-(anthracen-2-yl)-4,4-dimethyl-4,5-dihydrooxazole
• 英文别名: 2-[2'-(anthryl)]-4,4-dimethyl-2-oxazoline；2-anthracen-2-yl-4,4-dimethyl-5H-1,3-oxazole
• 化学式: C₁₉H₁₇NO
• 分子量: 275.35
• InChiKey: XJXRLCTYAFFGDT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(anthracen-2-yl)-4,4-dimethyl-4,5-dihydrooxazole 在 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex 、 氧气 作用下， 以 四氢呋喃 为溶剂， 25.0 ℃ 、101.33 kPa 条件下， 反应 30.0h， 以63%的产率得到3-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)anthracen-2-ol
  参考文献：
  名称：

  Aerobic C(sp²)–H Hydroxylations of 2-Aryloxazolines: Fast Access to Excited-State Intramolecular Proton Transfer (ESIPT)-Based Luminophores

  摘要：

  The direct hydroxylation of 2-aryloxazolines via a deprotonative magnesiation using TMPMgCl center dot LiCl and subsequent oxidation with molecular oxygen or air as a green oxidant is reported. This method proceeds under mild conditions at room temperature with high regioselectivity and chemoselectivity. The obtained phenols exhibit tunable luminescence properties, induced by excited-state intramolecular proton transfer. This method opens a new opportunity for the sustainable synthesis of luminescent organic molecules.

  DOI：

  10.1021/acs.orglett.9b01350
• 作为产物：
  描述：

  2-蒽甲酸 在 草酰氯 作用下， 以 二氯甲烷 为溶剂， 反应 20.0h， 生成 2-(anthracen-2-yl)-4,4-dimethyl-4,5-dihydrooxazole
  参考文献：
  名称：

  Anthryl-Substituted Heterocycles as Acid-Sensitive Fluorescence Probes

  摘要：

  Four pH-sensitive fluorescence probes are presented which consist of an anthracene fluorophore and a pi-conjugated oxazoline, benzoxazole, or pyridine substituent. The protonation of the heterocycles increases their acceptor properties and results in significant red-shifts of the absorption and emission maxima of the anthracene chromophore. The comparison between 2-[2'-(6'-methoxy-anthryl)]-4,4-dimethyl-2-oxazoline and 2-[2'-(anthryl)]-4,4-dimethyl-2-oxazoline reveals that the donor-acceptor substitution pattern of the fluorophore is not required to achieve a red shift upon protonation. The benzoxazole and pyridine substituents offer a particular advantage due to their persistence under acidic conditions. Thus, these compounds may be used as efficient pH-sensitive fluorescence switches. Nevertheless, the switching of benzoxazole 2c requires relatively strong acidic conditions. The anthrylpyridinium exhibits a red-shifted emission in chloroform; however, it is nonfluorescent in aqueous or alcoholic solution. Although the oxazoline is not persistent under permanent acidic conditions, this heterocycle may be useful as a substituent in fluorescence indicators since it may be used to detect acid concentrations of 10(-4)-10(-5) M, which are close to the biologically relevant range.

  DOI：

  10.1021/jo047841z

文献信息

• Aerobic C(sp²)–H Hydroxylations of 2-Aryloxazolines: Fast Access to Excited-State Intramolecular Proton Transfer (ESIPT)-Based Luminophores
  作者：Dominik Göbel、Nils Clamor、Enno Lork、Boris J. Nachtsheim

  DOI：10.1021/acs.orglett.9b01350

  日期：2019.7.19

  The direct hydroxylation of 2-aryloxazolines via a deprotonative magnesiation using TMPMgCl center dot LiCl and subsequent oxidation with molecular oxygen or air as a green oxidant is reported. This method proceeds under mild conditions at room temperature with high regioselectivity and chemoselectivity. The obtained phenols exhibit tunable luminescence properties, induced by excited-state intramolecular proton transfer. This method opens a new opportunity for the sustainable synthesis of luminescent organic molecules.
• Anthryl-Substituted Heterocycles as Acid-Sensitive Fluorescence Probes
  作者：Heiko Ihmels、Andreas Meiswinkel、Christian J. Mohrschladt、Daniela Otto、Michael Waidelich、Michael Towler、Rick White、Martin Albrecht、Alexander Schnurpfeil

  DOI：10.1021/jo047841z

  日期：2005.5.1

  Four pH-sensitive fluorescence probes are presented which consist of an anthracene fluorophore and a pi-conjugated oxazoline, benzoxazole, or pyridine substituent. The protonation of the heterocycles increases their acceptor properties and results in significant red-shifts of the absorption and emission maxima of the anthracene chromophore. The comparison between 2-[2'-(6'-methoxy-anthryl)]-4,4-dimethyl-2-oxazoline and 2-[2'-(anthryl)]-4,4-dimethyl-2-oxazoline reveals that the donor-acceptor substitution pattern of the fluorophore is not required to achieve a red shift upon protonation. The benzoxazole and pyridine substituents offer a particular advantage due to their persistence under acidic conditions. Thus, these compounds may be used as efficient pH-sensitive fluorescence switches. Nevertheless, the switching of benzoxazole 2c requires relatively strong acidic conditions. The anthrylpyridinium exhibits a red-shifted emission in chloroform; however, it is nonfluorescent in aqueous or alcoholic solution. Although the oxazoline is not persistent under permanent acidic conditions, this heterocycle may be useful as a substituent in fluorescence indicators since it may be used to detect acid concentrations of 10(-4)-10(-5) M, which are close to the biologically relevant range.