(Z)-Ethyl 3-(2-pyridinyl)-2-fluoropropenate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (Z)-Ethyl 3-(2-pyridinyl)-2-fluoropropenate
• 英文别名: ethyl 2-fluoro-3-(pyridin-2-yl)acrylate；(2Z)-3-(2-Pyridyl)-2-fluoro-2-propenoic Acid Ethyl Ester；ethyl (Z)-2-fluoro-3-pyridin-2-ylprop-2-enoate
• 化学式: C₁₀H₁₀FNO₂
• 分子量: 195.193
• InChiKey: BXYZAIZBRMSBJL-CLFYSBASSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (Z)-Ethyl 3-(2-pyridinyl)-2-fluoropropenate 在 水 、 sodium hydroxide 作用下， 以 甲醇 为溶剂， 以66 %的产率得到(Z)-2-fluoro-3-(pyridin-2-yl)acrylic acid
  参考文献：
  名称：

  [EN] TETRAHYDROPYRIDO 3,4-D PYRIMIDINE DERIVATIVES AS KRAS INHIBITORS
  [FR] DÉRIVÉS DE TÉTRAHYDROPYRIDO 3,4-D PYRIMIDINE UTILISÉS EN TANT QU'INHIBITEURS DE KRAS

  摘要：

  The present disclosure provides KRAS inhibitors. Methods of treating cancers using the compounds are also provided.

  公开号：

  WO2023240189A1
• 作为产物：
  描述：

  (E)-Ethyl 3-(2-pyridinyl)-2-fluoropropenate 在 碘 作用下， 以 甲苯 为溶剂， 以58 %的产率得到(Z)-Ethyl 3-(2-pyridinyl)-2-fluoropropenate
  参考文献：
  名称：

  [EN] TETRAHYDROPYRIDO 3,4-D PYRIMIDINE DERIVATIVES AS KRAS INHIBITORS
  [FR] DÉRIVÉS DE TÉTRAHYDROPYRIDO 3,4-D PYRIMIDINE UTILISÉS EN TANT QU'INHIBITEURS DE KRAS

  摘要：

  The present disclosure provides KRAS inhibitors. Methods of treating cancers using the compounds are also provided.

  公开号：

  WO2023240189A1

文献信息

• Modified Julia Fluoroolefination:  Selective Preparation of Fluoroalkenoates
  作者：Emmanuel Pfund、Cyril Lebargy、Jacques Rouden、Thierry Lequeux

  DOI：10.1021/jo070994c

  日期：2007.10.1

  The modified Julia olefination reaction has been applied to develop a stereoselective synthesis of fluoroalkenoate derivatives from a fluorobenzothiazolyl sulfone and aldehydes or a ketone. The olefination reaction can be achieved by using a variety of bases. DBU and DBU in the presence of MgBr2 were found to be the most efficient systems to prepare either (Z)- or (E)-alkenoates in moderate to excellent

  改性的朱莉娅烯化反应已用于开发从氟苯并噻唑基砜和醛或酮的氟代链烯酸酯衍生物的立体选择性合成。可以通过使用多种碱来实现烯化反应。发现在MgBr 2存在下，DBU和DBU是制备中度至优异的立体选择性的（Z）-或（E）-链烯酸酯的最有效系统。
• A Facile and Mild Approach for Stereoselective Synthesis of α-Fluoro-α,β-unsaturated Esters from α-Fluoro-β-keto Esters via Deacylation
  作者：Wenbin Yi、Jinlong Qian、Meifang Lv、Chun Cai

  DOI：10.1055/s-0034-1378917

  日期：——

  The highly stereoselective olefination reaction of α-fluoro-β-keto esters for the synthesis of α-fluoro-α,β-unsaturated esters has been developed. The olefination combines nucleophilic addition, intramolecular nucleophilic addition, and elimination in one step, as well as provides a facile synthetic approach to α-fluoro-α,β-unsaturated esters which are important units in many biologically active compounds

  α-氟-β-酮酯的高度立体选择性烯化反应用于合成α-氟-α,β-不饱和酯已经被开发出来。烯化在一个步骤中结合了亲核加成、分子内亲核加成和消除，并为α-氟-α,β-不饱和酯提供了一种简便的合成方法，α-氟-α,β-不饱和酯是许多生物活性化合物中的重要单元和各种有用的前体功能组转换。
• 16-halogen-epothilone derivatives, process for their production, and their pharmaceutical use
  申请人：Schering AG

  公开号：US20040014978A1

  公开（公告）日：2004-01-22

  The invention relates to novel epothilone derivatives of general formula (I), wherein R8 means a halogen atom, especially a fluorine or chlorine atom, and the remaining substituents have the meanings given in the description. The novel compounds are suitable for producing medicaments.

  本发明涉及一种新的环丙沙星衍生物，其一般式为（I），其中R8表示卤素原子，特别是氟或氯原子，其余取代基的含义如说明书所述。这种新化合物适用于制备药物。
• 16-Halogen-epothilone derivatives, method for producing them and their pharmaceutical use
  申请人：Klar Ulrich

  公开号：US20050187270A1

  公开（公告）日：2005-08-25

  A compound of formula C, BC and ABC.

  一个化学式为C、BC和ABC的化合物。
• Preparation of fluorinated alkenes in ionic liquids
  作者：Tomoya Kitazume、Genji Tanaka

  DOI：10.1016/s0022-1139(00)00331-6

  日期：2000.12

  The utility of ionic liquids (8-ethyl-1,8-diazabicyclo[5,4,0]-7-undecene trifluoromethanesulfonate and 8-methyl-1,8-diazabicydo[5,4,0]7-undecene trifluoromethanesulfonate) as a safe: recyclable reaction medium for the synthesis of alpha -fluoro-alpha,beta -unsaturated esters by the Horner-Wadsworth-Emmons reaction with aldehydes in the presence of base, is described. (C) 2000 Elsevier Science S.A. All rights reserved.