N-dimethylmethylene glycine-t-butyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-dimethylmethylene glycine-t-butyl ester
• 英文别名: Tert-butyl 2-(propan-2-ylideneamino)acetate
• 化学式: C₉H₁₇NO₂
• 分子量: 171.239
• InChiKey: LNFFTVLYIHMFRN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-dimethylmethylene glycine-t-butyl ester 、 4-氯苄溴 在 2,7-bis[O-9-allylhydrocinchonidinium-N-methyl]naphthalene dibromide 作用下， 以 氯仿 、 甲苯 为溶剂， 反应 2.5h， 以81%的产率得到
  参考文献：
  名称：

  EP1693362

  摘要：

  公开号：

文献信息

• Method for Producing Asymmetric Alkyl Compound Using Alkali-Treated Solid SAupport, and Alkali-Treated Solid Support Used in this Method
  申请人：Koshima Hideko

  公开号：US20070225157A1

  公开（公告）日：2007-09-27

  An asymmetric alkyl compound producing method of the present invention includes a synthesizing step of carrying out an asymmetric synthesis reaction by mixing (i) a reaction solution containing a glycine imine ester, an alkyl halide, and an asymmetric catalyst having a catalytic action which causes the asymmetric synthesis reaction to proceed with (ii) an alkali-treated solid support obtained by treating with an alkaline substance a solid support made of an inorganic compound. By placing this mixture at room temperature, the asymmetric alkylation occurs between the glycine imine ester and the alkyl halide which are catalyzed by the asymmetric catalyst in an alkali-treated solid support contained in the mixture, and the asymmetric alkylation is completed in about 1 hour. Thus, a highly optically pure asymmetric alkyl compound can be obtained in high yield. Therefore, it is possible to provide the asymmetric alkyl compound producing method which does not require the agitation of the solvent, completes the asymmetric alkylation efficiently and stably in a short time, and synthesizes a highly optically pure asymmetric alkyl compound in high yield.

  本发明的一种不对称烷基化合物的制备方法包括以下步骤：将（i）含有甘氨酸亚胺酯、烷基卤化物和具有催化作用的不对称催化剂的反应液与（ii）经过碱性物质处理的无机化合物制成的固体支撑物混合进行不对称合成反应的合成步骤。将该混合物放置于室温下，甘氨酸亚胺酯和烷基卤化物之间的不对称烷基化作用在混合物中含有碱性处理的固体支撑物的不对称催化剂的催化下发生，并在约1小时内完成不对称烷基化。因此，可以高产率地获得高度光学纯的不对称烷基化合物。因此，可以提供一种不需要溶剂搅拌，能够在短时间内高效稳定地完成不对称烷基化反应，并高产率合成高度光学纯的不对称烷基化合物的方法。
• PROCESS FOR PRODUCTION OF ASYMMETRIC ALKYL COMPOUNDS WITH ALKALI-TREATED SOLID CARRIER AND ALKALI-TREATED SOLID CARRIER TO BE USED IN THE PROCESS
  申请人：Japan Science and Technology Agency

  公开号：EP1693362A1

  公开（公告）日：2006-08-23

  An asymmetric alkyl compound producing method of the present invention includes a synthesizing step of carrying out an asymmetric synthesis reaction by mixing (i) a reaction solution containing a glycine imine ester, an alkyl halide, and an asymmetric catalyst having a catalytic action which causes the asymmetric synthesis reaction to proceed with (ii) an alkali-treated solid support obtained by treating with an alkaline substance a solid support made of an inorganic compound. By placing this mixture at room temperature, the asymmetric alkylation occurs between the glycine imine ester and the alkyl halide which are catalyzed by the asymmetric catalyst in an alkali-treated solid support contained in the mixture, and the asymmetric alkylation is completed in about 1 hour. Thus, a highly optically pure asymmetric alkyl compound can be obtained in high yield. Therefore, it is possible to provide the asymmetric alkyl compound producing method which does not require the agitation of the solvent, completes the asymmetric alkylation efficiently and stably in a short time, and synthesizes a highly optically pure asymmetric alkyl compound in high yield.

  本发明的不对称烷基化合物生产方法包括一个合成步骤，即通过将(i)含有甘氨酸亚胺酯、烷基卤化物和具有催化作用的不对称催化剂的反应溶液与(ii)通过用碱性物质处理无机化合物制成的固体支持物而获得的碱处理固体支持物混合，进行不对称合成反应。将该混合物置于室温下，甘氨酸亚胺酯和烷基卤化物在混合物中所含的碱处理固体载体中的不对称催化剂的催化下发生不对称烷基化反应，不对称烷基化反应大约在 1 小时内完成。因此，可以高产率获得高光学纯度的不对称烷基化合物。因此，不对称烷基化合物的生产方法无需搅拌溶剂，能在短时间内高效稳定地完成不对称烷基化反应，并能高产率合成高光学纯度的不对称烷基化合物。
• US7709678B2
  申请人：——

  公开号：US7709678B2

  公开（公告）日：2010-05-04
• EP1693362
  申请人：——

  公开号：——

  公开（公告）日：——