8-bromooctyltrimethylammonium bromide

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 8-bromooctyltrimethylammonium bromide
• 英文别名: 8-Bromooctyl(trimethyl)azanium;bromide
• 化学式: Br*C₁₁H₂₅BrN
• 分子量: 331.134
• InChiKey: DSLALLRPCDAKHT-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.43
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (4aS,6R,8aS)-11-甲基-5,6,9,10,11,12-六氢-4aH-[1]苯并呋喃并[3a,3,2-ef][2]苯并氮杂卓-3,6-二醇 、 8-bromooctyltrimethylammonium bromide 在 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以59%的产率得到6-O-demethyl-6-O-(8'-trimethylammoniumoctyl)-galanthamine bromide
  参考文献：
  名称：

  Potent acetylcholinesterase inhibitors: design, synthesis, and structure–Activity relationships of bis-interacting ligands in the galanthamine series

  摘要：

  New galanthamine derivatives, especially bis-interacting ligands 3-5 and 7-9 were prepared in order to interact with the catalytic and the peripheral sites of acetylcholinesterase (AChE). The synthesis, the anticholinesterase activities, and the structure-activity relationships of bis-interacting ligands are reported. Compounds 4d-e were found to be more potent than galanthamine and tacrine in inhibiting AChE. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(98)00133-3
• 作为产物：
  描述：

  1,8-二溴辛烷 、 三甲胺 以 四氢呋喃 为溶剂， 反应 24.0h， 以65%的产率得到8-bromooctyltrimethylammonium bromide
  参考文献：
  名称：

  侧链型阴离子交换膜通过燃料电池的柔性垫片带有季铵基侧基†

  摘要：

  为实现用于碱性燃料电池（AFC）的高性能阴离子交换膜（AEM），通过亲核缩聚，脱甲基化反应合成了一系列具有不同长度的柔性间隔基连接阳离子基团和主链的季铵化聚醚砜（PES）。和威廉姆森的反应。原子力显微镜（AFM）相图像显示了所有侧链型AEM的清晰的亲水/疏水相分离。PES- n- QA膜在阳离子基团和主链（苯环）之间具有亚己氧基间隔基（n = 6），表现出最大电导率为62.7 mS cm -1（IEC = 1.48 meq。g -1）在80°C下。的AEM材料被发现通过延伸所述柔性间隔物（的长度为具有改善的长期稳定性的碱性Ñ ≥4）。具有柔性十二烯氧基间隔基的PES-12-QA膜表现出最高的碱性稳定性，在60°C的1 M KOH水溶液中浸泡720 h后，电导率和IEC仅下降了8.1％和6.9％。此外，使用PES-6-QA作为AEM的单燃料电池性能测试显示，在60°C的电流密度为250 mA

  DOI：

  10.1039/c6ta05090e

文献信息

• Chemical agents
  申请人：The United States of America as represented by the Secretary of the Army

  公开号：US04241218A1

  公开（公告）日：1980-12-23

  New chemical compounds, bis-quaternary carbamates, having the generic fora: ##STR1## wherein X is one equivalent of an anion selected from monovalent or polyvalent anions, wherein n is 5-16, and wherein R, R.sub.1, R.sub.2 are aliphatic radicals selected from the group consisting of methyl, ethyl, propyl, isopropyl, and butyl, and having utility as toxic agents.

  新的化学化合物，双季铵氨基甲酸酯，其通用式为：##STR1## 其中X是来自单价或多价阴离子的一个当量，n为5-16，且R，R.sub.1，R.sub.2是从甲基，乙基，丙基，异丙基和丁基中选择的脂肪基，具有作为毒性剂的实用性。
• Process for removing bile salts from a patient and alkylated compositions therefor
  申请人：GelTex Pharmaceuticals, Inc.

  公开号：US20010044519A1

  公开（公告）日：2001-11-22

  The invention relates to a method for removing bile salts from a patient in need thereof and compositions useful in the method. The method comprises administering to the patient a therapeutically effective amount of a salt of an alkylated and crosslinked polymer. The alkylated and crosslinked polymer salt comprises the reaction product of crosslinked polymers, or salts and copolymers thereof having amine containing repeat units, with at least one aliphatic alkylating agent.

  本发明涉及一种从需要去除胆盐的患者中去除胆盐的方法和有用的组合物。该方法包括向患者施用一种烷基化和交联聚合物的盐的治疗有效量。烷基化和交联聚合物盐包括交联聚合物的反应产物，或其盐和共聚物，其中具有胺含有重复单元，并与至少一种脂肪族烷基化剂反应。
• PROCESS FOR REMOVING BILE SALTS FROM A PATIENT AND ALKYLATED COMPOSITIONS THEREOR
  申请人：GelTex Pharmaceuticals, Inc.

  公开号：US20020095002A1

  公开（公告）日：2002-07-18

  The invention relates to a method for removing bile salts from a patient in need thereof and compositions useful in the method. The method comprises administering to the patient a therapeutically effective amount of a salt of an alkylated and crosslinked polymer. The alkylated and crosslinked polymer salt comprises the reaction product of crosslinked polymers, or salts and copolymers thereof having amine containing repeat units, with at least one aliphatic alkylating agent.

  本发明涉及一种用于从需要此类治疗的患者中去除胆盐的方法和有用的组合物。该方法包括向患者投与一种烷基化和交联聚合物盐的治疗有效量。所述烷基化和交联聚合物盐包括交联聚合物或其盐和共聚物，其具有含有氨基重复单元的结构，与至少一种脂肪族烷基化试剂反应生成的产物。
• Alkylated poly(allylamine) polymers and methods of use
  申请人：Mandeville Harry W.

  公开号：US20070155950A1

  公开（公告）日：2007-07-05

  The invention relates to a method for removing bile salts from a patient in need thereof and compositions useful in the method. The method comprises administering to the patient a therapeutically effective amount of a salt of an alkylated and crosslinked polymer. The alkylated and crosslinked polymer salt comprises the reaction product of crosslinked polymers, or salts and copolymers thereof having amine containing repeat units, with at least one aliphatic alkylating agent.

  本发明涉及一种用于从需要的患者中去除胆盐的方法和用于该方法的组合物。该方法包括向患者施用一种烷基化和交联聚合物的盐的治疗有效量。烷基化和交联聚合物盐包括具有含胺重复单元的交联聚合物或其盐和共聚物的反应产物，与至少一种脂肪族烷基化剂反应。
• PROCESS FOR REMOVING BILE SALTS FROM A PATIENT AND ALKYLATED COMPOSITIONS THEREFOR
  申请人：GELTEX PHARMACEUTICALS, INC.

  公开号：EP0764174A1

  公开（公告）日：1997-03-26