(+/-)-3-(1-pyrrolidinyl)butyric acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (+/-)-3-(1-pyrrolidinyl)butyric acid
• 英文别名: 3-(pyrrolidin-1-yl)butanoic acid；3-pyrrolidin-1-ium-1-ylbutanoate
• 化学式: C₈H₁₅NO₂
• mdl: MFCD09971252
• 分子量: 157.213
• InChiKey: OVWPFTZHEITDRW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (+/-)-3-(1-pyrrolidinyl)butyric acid methyl ester 在 sodium hydroxide 作用下， 反应 4.5h， 生成 (+/-)-3-(1-pyrrolidinyl)butyric acid
  参考文献：
  名称：

  Essawi, Pharmazie, 1999, vol. 54, # 8, p. 575 - 579

  摘要：

  DOI：

文献信息

• [EN] HIGHLY SELECTIVE NOVEL AMIDATION METHOD<br/>[FR] PROCÉDÉ D'UNE NOUVELLE AMIDATION TRÈS SÉLECTIVE
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2005121133A1

  公开（公告）日：2005-12-22

  The present invention provides an industrial production method with a short process having a high yield of an aliphatic cyclic carboxamide having carboxyl group, which comprises reacting functional group-selectively using an inexpensive condensing agent without protecting the carboxyl group by esterification, that is, reacting carboxylic acid anhydride obtained by reacting carboxylic acid and tertiary carboxylic acid halide with aliphatic cyclic secondary amine having carboxyl group.

  本发明提供了一种工业生产方法，该方法具有短流程、高产率，用于制备含有羧基的脂肪族环状酰胺，其特点在于使用廉价的缩合剂对功能团进行选择性反应，而不通过酯化保护羧基，即通过将由羧酸与叔羧酸卤化物反应得到的羧酸酐与含有羧基的脂肪族环状仲胺进行反应。
• Addition of cyclic amines to α,β-unsaturated acids via the aza-Michael reaction
  作者：H. N. Khachatryan、G. A. Bagdasaryan、S. S. Hayotsyan、O. S. Attaryan、G. G. Danagulyan

  DOI：10.1134/s1070363216080302

  日期：2016.8

  Addition of Cyclic Amines to α,β-Unsaturated Acids via the Aza-Michael Reaction H. N. Khachatryan, G. А. Bagdasaryan, S. S. Hayotsyan, O. S. Attaryan, and G. G. Danagulyan a Institute of Organic Chemistry, Scientific-Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia Azatutyan ave. 26, Yerevan, 0014 Armenia *e-mail: [e-mail] b Russian-Armenian

  通过 Aza-Michael 反应将环胺添加到 α,β-不饱和酸中 HN Khachatryan, G. Bagdasaryan、SS Hayotsyan、OS Attaryan 和 GG Danagulyan 亚美尼亚国家科学院有机化学和药物化学科学技术中心有机化学研究所 Azatutyan ave。26, Yerevan, 0014 Armenia *e-mail: [e-mail] b 俄罗斯-亚美尼亚（斯拉夫）大学，亚美尼亚埃里温
• Highly Selective Novel Amidation Method
  申请人：Inagaki Atsushi

  公开号：US20070238721A1

  公开（公告）日：2007-10-11

  The present invention provides an industrial production method with a short process having a high yield of an aliphatic cyclic carboxamide having carboxyl group, which comprises reacting functional group-selectively using an inexpensive condensing agent without protecting the carboxyl group by esterification, that is, reacting carboxylic acid anhydride obtained by reacting carboxylic acid and tertiary carboxylic acid halide with aliphatic cyclic secondary amine having carboxyl group.

  本发明提供了一种工业生产方法，该方法具有短工艺流程，高产率，用廉价的缩合剂进行功能基选择性反应，不需要通过酯化来保护羧基，即将羧酸和三级羧酸卤化物反应得到羧酸酐，然后与具有羧基的脂环状二级胺反应。
• HIGHLY SELECTIVE NOVEL AMIDATION METHOD
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1753752A1

  公开（公告）日：2007-02-21
• PATTERNING PROCESS AND PATTERN SURFACE COATING COMPOSITION
  申请人：HATAKEYAMA Jun

  公开号：US20090053657A1

  公开（公告）日：2009-02-26

  A pattern is formed by applying a first positive resist composition comprising a polymer comprising recurring units which become alkali soluble under the action of acid onto a substrate to form a first resist coating, heat treating, exposing, heat treating, developing to form a first resist pattern, applying a pattern surface coating composition comprising a hydroxyl-containing crosslinkable polymer onto the first resist pattern and crosslinking, thereby covering the first resist pattern with a crosslinked polymer film, applying a second positive resist composition thereon, heat treating, exposing, heat treating, and developing to form a second resist pattern.