培尼洛尔 | 58503-83-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 培尼洛尔
• 中文别名: 派尼罗醇
• 英文名称: 1-(o-cyanophenoxy)-2-hydroxy-3-<(α,α-dimethyl-n-propyl)amino>propane
• 英文别名: 2-(3-((1,1-dimethylpropyl)amino)-2-hydroxypropoxy)-benzonitrile；penirolol；2-[2-hydroxy-3-(2-methylbutan-2-ylamino)propoxy]benzonitrile
• CAS: 58503-83-6
• 化学式: C₁₅H₂₂N₂O₂
• 分子量: 262.352
• InChiKey: MMKLQZPUMDLVHF-UHFFFAOYSA-N

物化性质

• 沸点：
  426.1±35.0 °C(Predicted)
• 密度：
  1.07±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  65.3
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Pharmaceutical preparation comprising an active dispersed on a matrix
  申请人：——

  公开号：US20040058896A1

  公开（公告）日：2004-03-25

  The present invention relates to the field of pharmaceutical technology and describes a novel advantageous preparation for an active ingredient. The novel preparation is suitable for producing a large number of pharmaceutical dosage forms. In the new preparation an active ingredient is present essentially uniformly dispersed in an excipient matrix composed of one or more excipients selected from the group of fatty alcohol, triglyceride, partial glyceride and fatty acid ester.

  本发明涉及制药技术领域，描述了一种新的有利的活性成分制备方法。这种新的制备方法适用于生产大量的药物剂型。在这种新的制备方法中，活性成分基本上均匀地分散在由脂肪醇、甘油三酯、部分甘油酯和脂肪酸酯等多种赋形剂中选择的一种或多种赋形剂组成的赋形剂基质中。
• Method of preparing a heterocyclic intermediate for the production of optically active aryloxysubstituted vicinal aminoalcohols
  申请人：DUPHAR INTERNATIONAL RESEARCH B.V

  公开号：EP0647633A1

  公开（公告）日：1995-04-12

  The invention relates to a method of preparing a heterocyclic intermediate of the general formula wherein    X is a carbonyl group, a thiocarbonyl group, a (C₁-C₁₀)(ar)alkylidene group or a dihydrocarbylsilyl group,    R is a straight or branched (C₁-C₁₀)alkyl group, optionally substituted with halogen, hydroxy, (C₁-C₄)alkoxy or protected hydroxy, or a phenyl(C₁-C₃)alkyl or heteroaryl(C₁-C₃)alkyl group, which groups are optionally substituted with 1-3 substituents, selected from the group consisting of hydroxy, (C₅-C₁₂)cycloalkyl, amino, nitro, halogen, cyano, alkoxy, alkylcarbonyloxy, alkylcarbonylamino, alkylsulphonylamino, alkylsulphonyl, alkylcarbonyl, and alkyl, wherein the alkyl groups have 1-5 carbon atoms, and which intermediate has either the R or the S configuration, by subjecting an optically active cyanohydrin of the general formula to a reduction-transimination-reduction sequence, using R - NH₂ as the primary amine, followed by a cyclization reaction and, finally, by an ozonolysis-reduction sequence.

  本发明涉及一种制备杂环中间体的方法，其通式如下：其中X为羰基，硫代羰基，(C₁-C₁₀)(芳)烷基亚甲基或二氢基碳基硅基，R为直链或支链(C₁-C₁₀)烷基，可选用卤素、羟基、(C₁-C₄)烷氧基或保护羟基进行取代，或苯基(C₁-C₃)烷基或杂环芳基(C₁-C₃)烷基，这些基团可选用1-3个取代基进行取代，所述取代基选自羟基、(C₅-C₁₂)环烷基、氨基、硝基、卤素、氰基、烷氧基、烷基羰氧基、烷基羰基氨基、烷基磺酰胺基、烷基磺酰基、烷基羰基和烷基，其中烷基含有1-5个碳原子，该中间体具有R或S构型，通过将手性氰醇通式的还原-转移-还原序列，使用R-NH₂作为主要胺，然后进行环化反应，最后进行臭氧化-还原序列。
• [EN] CYCLOPROPYL MODULATORS OF P2Y12 RECEPTOR<br/>[FR] MODULATEURS CYCLOPROPYLÉS DU RÉCEPTEUR P2Y12
  申请人：AUSPEX PHARMACEUTICALS INC

  公开号：WO2011017108A2

  公开（公告）日：2011-02-10

  The present invention relates to new cyclopropyl modulators of P2Y12 receptor activity, pharmaceutical compositions thereof, and methods of use thereof.

  本发明涉及新的环丙基P2Y12受体调节剂，其制药组合物以及使用方法。
• CYCLOPROPYL MODULATORS OF P2Y12 RECEPTOR
  申请人：Auspex Pharmaceuticals, Inc.

  公开号：US20160193212A1

  公开（公告）日：2016-07-07

  The present invention relates to new cyclopropyl modulators of P2Y12 receptor activity, pharmaceutical compositions thereof, and methods of use thereof.

  本发明涉及P2Y12受体活性的新环丙基调节剂，其制药组合物以及使用方法。
• DEUTERATED DERIVATIVES OF TICAGRELOR FOR MEDICAL USE
  申请人：Auspex Pharmaceuticals, Inc.

  公开号：EP3135675A1

  公开（公告）日：2017-03-01

  The present invention relates to deuterated compounds having a modulatory activity at the P2Y12 receptor for use in the treatment of myocardial infarction, stroke or acute coronary syndrome.

  本发明涉及具有调节P2Y12受体活性的氘代化合物，用于治疗心肌梗死、中风或急性冠状动脉综合征。