多法氯铵 | 54063-35-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 多法氯铵
• 英文名称: [2-(lauroyl-methyl-amino)-ethyl]-dimethyl-(phenylcarbamoyl-methyl)-ammonium; chloride
• 英文别名: [2-(Lauroyl-methyl-amino)-aethyl]-dimethyl-(phenylcarbamoyl-methyl)-ammonium; Chlorid；Dofamiumchlorid；dofanium chloride；2-[{2-[Dodecanoyl(methyl)amino]ethyl}(dimethyl)azaniumyl]-N-phenylethanimidate--hydrogen chloride (1/1)；2-[2-[dodecanoyl(methyl)amino]ethyl-dimethylazaniumyl]-N-phenylethanimidate;hydrochloride
• CAS: 54063-35-3
• 化学式: C₂₅H₄₄N₃O₂*Cl
• 分子量: 454.096
• InChiKey: AOAQBXAGGBSALU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.08
• 重原子数：
  31
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氯乙酰苯胺 、 alkaline earth salt of/the/ methylsulfuric acid 生成 多法氯铵
  参考文献：
  名称：

  Quaternary ammonium compounds and their manufacture

  摘要：

  公开号：

  US02644003A1

文献信息

• Composition and related method for inhibiting moisture loss from skin
  申请人：Access Business Group International LLC

  公开号：US10307366B2

  公开（公告）日：2019-06-04

  A method useful for inhibiting moisture loss from skin comprises the step of administering a composition to a subject's skin. The composition comprises a first humectant and a second humectant different from the first humectant. The humectants are useful for increasing moisture content of the subject's skin, specifically the subject's epidermis. The first humectant may comprise a conventional humectant, e.g. glycerol. The second humectant generally comprises certain types of honey. The honey is capable of inhibiting moisture loss from the subject's epidermis and/or moisture loss from the first humectant when the subject is exposed to dry air conditions, e.g. wintertime air having a relative humidity of about 50% or less. Specifically, the second humectant is useful for mitigating adverse effects of the first humectant under certain conditions. Examples of suitable honeys generally include those comprising the flavanone hesperidin, such as orange blossom honey, buckwheat (blossom) honey, or a combination thereof.

  一种用于抑制皮肤水分流失的方法包括向受试者的皮肤施用一种组合物。该组合物包括第一保湿剂和不同于第一保湿剂的第二保湿剂。保湿剂有助于增加受试者皮肤，特别是表皮的含水量。第一保湿剂可包括常规保湿剂，如甘油。第二保湿剂一般包括某些类型的蜂蜜。当受试者暴露在干燥的空气条件下，例如相对湿度约为 50%或更低的冬季空气中时，蜂蜜能够抑制受试者表皮的水分流失和/或第一保湿剂的水分流失。具体来说，第二保湿剂可以在某些条件下减轻第一保湿剂的不利影响。合适的蜂蜜通常包括含有黄酮橙皮甙的蜂蜜，如橙花蜂蜜、荞麦（花）蜂蜜或它们的组合。
• Wound closure systems for reducing surgical site infections comprising incision drapes filled with releasable antimicrobial agents
  申请人：Ethicon, Inc.

  公开号：US11452641B2

  公开（公告）日：2022-09-27

  A surgical incision drape, comprises a flexible substantially flat areal substrate having an upper side and an opposing tissue-facing side, having a longitudinal axis and a pressure sensitive adhesive disposed on the tissue-facing side; at least one hollow microtubular compartment containing a flowable medical agent, said hollow microtubular compartment positioned to intersect the longitudinal axis and embedded into the substrate or positioned on the substrate.

  一种手术切口敷料，包括一个柔性大体平坦的基底，基底有一个上侧和一个相对的面向组织的侧，基底有一个纵轴，面向组织的侧上有一个压敏粘合剂；至少一个中空微管隔室，内装可流动的医用制剂，所述中空微管隔室的位置与纵轴相交，并嵌入基底或设置在基底上。
• Antimicrobial polymer
  申请人：——

  公开号：US20030157193A1

  公开（公告）日：2003-08-21

  A polymeric composition having antimicrobial properties and a process for rendering the surface of a substrate antimicrobial are disclosed. The composition comprises a crosslinked chemical combination of (i) a polymer having amino group-containing side chains along a backbone forming the polymer, (ii) an antimicrobial agent selected from quaternary ammonium compounds, gentian violet compounds, substituted or unsubstituted phenols, biguanide compounds, iodine compounds, and mixtures thereof, and (iii) a crosslinking agent containing functional groups capable of reacting with the amino groups. In one embodiment, the polymer is a polyamide formed from a maleic anhydride or maleic acid ester monomer and alkylamines thereby producing a polyamide having amino substituted alkyl chains on one side of the polyamide backbone; the crosslinking agent is a phosphine having the general formula (A) 3 P wherein A is hydroxyalkyl; and the antimicrobial agent is chlorhexidine, dimethylchlorophenol, cetyl pyridinium chloride, gentian violet, triclosan, thymol, iodine, and mixtures thereof.

  本发明公开了一种具有抗菌特性的聚合物组合物和一种使基底表面具有抗菌性的工艺。该组合物包括以下物质的交联化学组合：(i) 沿着形成聚合物的骨架具有含氨基侧链的聚合物；(ii) 选自季铵化合物、龙胆紫化合物、取代或未取代的苯酚、双胍化合物、碘化合物及其混合物的抗菌剂；(iii) 含能与氨基反应的官能团的交联剂。在一个实施方案中，聚合物是由马来酸酐或马来酸酯单体和烷基胺形成的聚酰胺， 从而产生在聚酰胺主链一侧具有氨基取代烷基链的聚酰胺；交联剂是具有通式 (A) 的膦 3 P 其中 A 为羟烷基；抗菌剂为洗必泰、二甲基氯苯酚、十六烷基氯化吡啶、龙胆紫、三氯生、百里酚、碘及其混合物。
• AN OIL-IN-WATER EMULSION FOR USE ON HUMAN SKIN FOR CLEANSING, PRESERVING OR IMPROVING THE CONDITION OF THE SKIN
  申请人：Plum Kemi Produktion A/S

  公开号：EP0915693A1

  公开（公告）日：1999-05-19
• WOUND CLOSURE SYSTEMS FOR REDUCING SURGICAL SITE INFECTIONS COMPRISING INCISION DRAPES FILLED WITH RELEASABLE ANTIMICROBIAL AGENTS
  申请人：Ethicon, Inc

  公开号：EP3989865A1

  公开（公告）日：2022-05-04