sodium methyl mercaptan

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醇
• 英文名称: sodium methyl mercaptan
• 英文别名: sodium salt of methanethiol；Sodium;methanethiol
• 化学式: CH₄S*Na
• mdl: MFCD00174316
• 分子量: 71.0985
• InChiKey: RMBAVIFYHOYIFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.84
• 重原子数：
  3
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  sodium methyl mercaptan 、 2-溴甲基-1-氟-4-硝基苯 以 乙醇 为溶剂， 反应 2.0h， 以85%的产率得到(2-fluoro-5-nitrobenzyl)(methyl)sulfane
  参考文献：
  名称：

  一种选择性钠通道调节剂及其制备和应用

  摘要：

  本发明提供了作为选择性钠通道调节剂的化合物及合成和使用方法，具体地，本发明提供了一种如式(I)所示的化合物，及其制备方法和作为选择性钠通道调节剂的用途。所述的化合物表现出作为钠通道调节剂的优异活性。

  公开号：

  CN112300069A
• 作为试剂：
  描述：

  4-chloro-5-ethoxycarbonylbenzothiophene 1,1-dioxide 在 sodium methyl mercaptan 、 四丁基溴化铵 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 生成 4-chloro-5-ethoxycarbonyl-2-methylthio-2,3-dihydrobenzothiophene 1,1-dioxide
  参考文献：
  名称：

  Benzothiophene derivatives and herbicidal compositions containing the same

  摘要：

  本发明的苯并噻吩衍生物由通式（I）表示：其中R1至R7、X、Y、Q、n和p如规范中所定义。含有苯并噻吩衍生物作为有效成分的除草剂组合物对于栽培作物如稻谷的伤害较小，并且在低施用率下对于杂草的生长控制具有广谱作用。

  公开号：

  US20040058957A1

文献信息

• Heterocyclic indole derivatives and mono- or diazaindole derivatives
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：US06673797B1

  公开（公告）日：2004-01-06

  There is provided a compound represented by the general formula (1): wherein Het represents an optionally substituted heterocyclic group; A1 and A2 each independently represent —CH═, etc.; A3 represents —CH2—, etc.; R1 represents a 4-fluorophenyl group, etc.; R2 represents an alkyl group; n represents 0, 1 or 2, provided that when A1 and A2 both are —CH═, A3 represents —CH2— or —SO2—, which is an indole derivative or a mono- or diazaindole derivative that has COX-2 inhibitory activity and is useful as a pharmaceutical, such as an anti-inflammatory agent, or addition salts thereof with a pharmaceutically acceptable acid or base, or hydrates thereof.

  提供一种化合物，其一般式表示为（1）：其中Het代表可选择地取代的杂环基团；A1和A2各自独立地表示—CH═等；A3表示—CH2—等；R1表示4-氟苯基团等；R2表示烷基团；n表示0、1或2，但当A1和A2都为—CH═时，A3表示—CH2—或—SO2—，它是一种COX-2抑制活性的吲哟衍生物或单或二氮杂吲哟衍生物，可用作药物，如抗炎药物，或其与药用可接受的酸或碱形成的加合盐，或其水合物。
• 一种盐酸奈康唑的制备方法
  申请人：扬子江药业集团广州海瑞药业有限公司

  公开号：CN112194628A

  公开（公告）日：2021-01-08

  本发明公开一种盐酸奈康唑的制备方法。制备方法包括如下步骤：(1)以式III化合物和溴戊烷为反应原料，在碱性条件下反应，对反应得到的产物进行萃取；萃取分离出的有机产物与氯化氢反应成盐，得到盐酸奈康唑；任选地，还包括步骤(2)：对上述得到的盐酸奈康唑进行精制。本发明方法通过严格控制各中间体制备的反应条件、中间体后处理过程以及盐酸奈康唑精制过程，制备得到的盐酸奈康唑的纯度高，残留溶剂和杂质含量非常低。得到的盐酸奈康唑还具有优异的稳定性。
• 一种苯唑草酮的制备方法
  申请人：江苏七洲绿色化工股份有限公司

  公开号：CN112125898B

  公开（公告）日：2021-10-08

  本发明涉及一种苯唑草酮的制备方法，其包括如下步骤：步骤(1)、化合物5在催化剂作用下，与氧化剂发生氧化反应得到化合物6；步骤(2)、化合物6与镁、二氧化碳发生格式反应得到化合物7；步骤(3)、化合物7与1‑甲基‑5‑羟基吡唑发生缩合反应得到苯唑草酮，其中，所述的化合物5的结构式为所述的化合物6的结构式为所述的化合物7的结构式为本发明的苯唑草酮的制备方法副产物较少，苯唑草酮的纯度和收率高，废水处理难度小、成本低，生产过程中无毒副作用，适合工业化生产。
• New Insights into the Design of Inhibitors of Human <i>S</i>-Adenosylmethionine Decarboxylase: Studies of Adenine C⁸ Substitution in Structural Analogues of <i>S</i>-Adenosylmethionine
  作者：Diane E. McCloskey、Shridhar Bale、John A. Secrist、Anita Tiwari、Thomas H. Moss、Jacob Valiyaveettil、Wesley H. Brooks、Wayne C. Guida、Anthony E. Pegg、Steven E. Ealick

  DOI：10.1021/jm801126a

  日期：2009.3.12

  S-adenosylmethionine decarboxylase (AdoMetDC) is a critical enzyme in the polyamine biosynthetic pathway and depends on a pyruvoyl group for the decarboxylation process. The crystal structures of the enzyme with various inhibitors at the active site have shown that the adenine base of the ligands adopts an unusual syn conformation when bound to the enzyme. To determine whether compounds that favor the syn conformation in solution would be more potent AdoMetDC inhibitors, several series of AdoMet substrate analogues with a variety of substituents at the 8-position of adenine were synthesized and analyzed for their ability to inhibit hAdoMetDC. The biochemical analysis indicated that an 8-methyl substituent resulted in more potent inhibitors, yet most other 8-substitutions provided no benefit over the parent compound. To understand these results, we used computational modeling and X-ray crystallography to study C(8)-substituted adenine analogues bound in the active site.
• Synthesis and structure–activity relationships of novel substituted 8-amino, 8-thio, and 1,8-pyrazole congeners of antitubercular rifamycin S and rifampin
  作者：Yafei Jin、Sumandeep K. Gill、Paul D. Kirchhoff、Baojie Wan、Scott G. Franzblau、George A. Garcia、H.D. Hollis Showalter

  DOI：10.1016/j.bmcl.2011.08.054

  日期：2011.10

  A series of rifamycin S and rifampin analogues incorporating substituted 8-amino, 8-thio, and 1,8-pyrazole substituents has been synthesized. The compounds were made by activation of the C-8 phenol as a sulfonate ester, followed by displacement with selected nitrogen and sulfur nucleophiles. The analogues were screened in assays to quantify their antitubercular activity under both aerobic and anaerobic conditions, and for inhibition of wild-type Mycobacterium tuberculosis (MTB) RNAP and rifamycin-resistant MTB RNAP (S450L) via an in vitro rolling circle transcription assay. Additionally, the MIC(90) values were determined for these analogues against Escherichia coli strains. Although none of the analogues displayed superior enzymatic or microbiological activity to their parent scaffolds, the results are consistent with the Rif C-8 hydroxyl acting as a hydrogen bond acceptor with S450 and that Rif resistance in the S450L mutant is due to loss of this hydrogen bond. Representative analogues were also evaluated in the human pregnane X receptor (PXR) activation assay. (C) 2011 Elsevier Ltd. All rights reserved.