3,4-dichloro-4'-methylbiphenyl

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,4-dichloro-4'-methylbiphenyl
• 英文别名: 1,2-Dichloro-4-(4-methylphenyl)benzene
• 化学式: C₁₃H₁₀Cl₂
• 分子量: 237.128
• InChiKey: FMUQJVUAAQUFNZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  3,4-二氯碘苯 、 在 copper(l) iodide 、 N,N-dimethyl-2-(diphenylphosphino)aniline 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以161.2 mg的产率得到3,4-dichloro-4'-methylbiphenyl
  参考文献：
  名称：

  Copper-catalysed cross-coupling of arylzirconium reagents with aryl and heteroaryl iodides

  摘要：

  报道了一种前所未有的Cu催化的芳基锆试剂与芳基和杂环碘化物的偶联反应。与Cp₂ZrAr_{2>复合物的机理研究表明，Cp2Zr(Ar)(Cl)是发生与(PN-1)CuI的跨金属化反应的活性物种。}

  DOI：

  10.1039/c5cc00116a

文献信息

• [EN] GLUCAGON ANTAGONISTS<br/>[FR] ANTAGONISTES DE GLUCAGON
  申请人：METABASIS THERAPEUTICS INC

  公开号：WO2010019830A1

  公开（公告）日：2010-02-18

  Provided herein are compounds, including enantiomerically pure forms thereof, and pharmaceutically acceptable salts or co-crystals and prodrugs thereof which have glucagon receptor antagonist or inverse agonist activity. Further, provided herein are pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucagon receptor antagonist is indicated, including Type I and II diabetes, insulin resistance and hyperglycemia. Moreover, provided herein are methods of making or manufacturing compounds disclosed herein, including enantiomerically pure forms thereof, and pharmaceutically acceptable salts or Co- crystals and prodrugs thereof. Formula I

  本文提供了化合物，包括其对映体纯形式，以及具有胰高血糖素受体拮抗剂或逆向激动剂活性的药用盐或共晶体和前药。此外，本文提供了包括这些化合物的药物组合物，以及治疗、预防、延缓发病时间或减少一种或多种胰高血糖素受体拮抗剂适用的疾病或病情的发展或进展风险的方法，包括I型和II型糖尿病、胰岛素抵抗和高血糖。此外，本文提供了制备或生产本文披露的化合物的方法，包括其对映体纯形式，以及药用盐或共晶体和前药。公式I
• Manganese(iii) acetate-mediated oxidative coupling of phenylhydrazines with benzene: a novel method for biaryl coupling
  作者：Ayhan S. Demir、Ömer Reis、Emine Özgül-Karaaslan

  DOI：10.1039/b105119a

  日期：2001.11.15

  The reaction of phenylhydrazines with benzene in the presence of manganese(III) acetate affords biaryls in good yields. The same reaction was carried out with similar oxidants, such as CoIII, CeIV and PbIV; among these oxidants MnIII acetate shows higher efficiency and selectivity.

  在醋酸锰（III）存在下，苯肼与苯反应生成双芳基化合物，产率很高。同样的反应也使用了类似的氧化剂，如 CoIII、CeIV 和 PbIV；在这些氧化剂中，醋酸锰 III 显示出更高的效率和选择性。
• [EN] USE OF COMPOSITIONS MODULATING CHROMATIN STRUCTURE FOR GRAFT VERSUS HOST DISEASE (GVHD)<br/>[FR] UTILISATION DE COMPOSITIONS MODULANT LA STRUCTURE DE LA CHROMATINE CONTRE LA MALADIE DU GREFFON CONTRE L'HÔTE (GVHD)
  申请人：DANA FARBER CANCER INST INC

  公开号：WO2016073903A1

  公开（公告）日：2016-05-12

  In some aspects, the instant disclosure relates to methods of treating chronic graft versus host disease (cGVHD). In some embodiments, the method comprises administering to a subject in need thereof a EZH2 inhibitor, a Bcl6 inhibitor and/or BRD4 inhibitor. The present disclosure is based, at least in part, on the discovery that enhancer of zeste homolog 2 (EZH2) inhibitors, B-cell lymphoma 6 protein (Bcl6) inhibitors and/or bromodomain-containing protein 4 (BRD4) inhibitors can be used to treat chronic graft versus host disease (cGVHD).

  在某些方面，瞬时披露涉及治疗慢性移植物抗宿主病（cGVHD）的方法。在某些实施例中，该方法包括向需要该方法的受试者施用EZH2抑制剂、Bcl6抑制剂和/或BRD4抑制剂。本公开至少部分地基于发现，增强子of zeste同源物2（EZH2）抑制剂、B细胞淋巴瘤6蛋白（Bcl6）抑制剂和/或含有bromodomain的蛋白4（BRD4）抑制剂可用于治疗慢性移植物抗宿主病（cGVHD）。
• Pyrimidinone Derivatives and Their Use as a Drug
  申请人：Poitout Lydie

  公开号：US20090325933A1

  公开（公告）日：2009-12-31

  The present application relates to new pyrimidinone derivatives. These products have a good affinity for certain sub-types of cannabinoid receptors, especially the CB2 receptors. They are particularly attractive for treating pathological conditions and diseases in which one or more cannabinoid receptors are involved. The invention also relates to pharmaceutical compositions containing said products and their use for the preparation of a drug.

  本申请涉及新的嘧啶酮衍生物。这些产品对某些亚型的大麻素受体，特别是CB2受体具有良好的亲和力。它们特别适用于治疗涉及一个或多个大麻素受体的病理状况和疾病。本发明还涉及含有上述产品的药物组合物及其用于制备药物的用途。
• SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE
  申请人：Parmee Emma

  公开号：US20090215825A1

  公开（公告）日：2009-08-27

  The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.

  本发明涉及取代的吡唑，包含此类化合物的组合物和治疗方法。这些化合物是胰高血糖素受体拮抗剂，因此可用于治疗、预防或延缓2型糖尿病的发生。