DH-2-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: DH-2-8
• 英文别名: 2,3-Dihydroxy-6-methyl-5-naphthalen-1-ylcyclohepta-2,4,6-trien-1-one；2,3-dihydroxy-6-methyl-5-naphthalen-1-ylcyclohepta-2,4,6-trien-1-one
• 化学式: C₁₈H₁₄O₃
• 分子量: 278.307
• InChiKey: BSQNYQJEAFDCFV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-hydroxy-4-methoxy-2-methylpyrylium trifluoromethanesulfonate 在 三氟甲磺酸 、 N,N-二异丙苯胺 、 氢溴酸 、 溶剂黄146 作用下， 以 氘代氯仿 、 二氯甲烷 为溶剂， 反应 8.5h， 生成 DH-2-8
  参考文献：
  名称：

  [EN] HYDROXYLATED TROPOLONE INHIBITORS OF NUCLEOTIDYL TRANSFERASES IN HERPESVIRUS AND HEPATITS B AND USES THEREFOR
  [FR] INHIBITEURS HYDROXYLÉS DE TROPOLONE DE NUCLÉOTIDYL-TRANSFÉRASES UTILISÉS DANS LE TRAITEMENT DU VIRUS DE L'HERPÈS ET DE L'HÉPATITE B ET LEURS UTILISATIONS

  摘要：

  本公开涉及抑制疱疹病毒核酸代谢和乙型肝炎病毒的抑制剂。还提供了使用这些药剂的治疗方法。

  公开号：

  WO2016201243A1

文献信息

• [EN] ANTI-FUNGAL COMPOUNDS<br/>[FR] COMPOSÉS ANTIFONGIQUES
  申请人：UNIV SAINT LOUIS

  公开号：WO2017184752A1

  公开（公告）日：2017-10-26

  The present disclosure provides compounds of the formula (I), (II), (III), wherein the variables are as defined herein for use in the treatment of fungal infections. In some embodiments, the fungal infection is an infection of Cryptococcus neojormans fungus. Also provided herein are compositions comprising a compound of formula I, II, or III and a second anti-fungal agent.

  本公开提供式(I)、(II)、(III)的化合物，其中变量的定义如本文所述，用于治疗真菌感染。在某些实施例中，真菌感染是新隆头菌真菌感染。此外，本文还提供包括式(I)、(II)或(III)的化合物和第二种抗真菌剂的组合物。
• Traceless solid-phase α-hydroxytropolone synthesis
  作者：Michael P. D'Erasmo、Takashi Masaoka、Jennifer A. Wilson、Errol M. Hunte、John A. Beutler、Stuart F. J. Le Grice、Ryan P. Murelli

  DOI：10.1039/c6md00237d

  日期：——

  first solid-phase synthesis of α-hydroxytropolones. We also showed that, while minor impurities exist after cleavage and aqueous wash, the semi-crude products display activity in HIV RT-associated RNaseH enzymatic and cell-based assays consistent with pure molecules made in solution phase. These proof-of-principle studies demonstrate the feasibility of solid-phase α-hydroxytropolone synthesis and its

  α-羟维酮是几种治疗相关的双核金属酶的公认抑制剂，因此是各种人类疾病的主要药物靶标。我们在α-羟基对苯二酚的第一个固相合成中利用了最近公开的三组分氧化吡啶环加成反应。我们还表明，尽管裂解和水洗后存在少量杂质，但半粗产物在与HIV RT相关的RNaseH酶促和基于细胞的测定中显示出与溶液相中纯分子一致的活性。这些原理验证研究证明了固相合成α-羟基马酚的可行性以及其作为基于α-羟基马酚的药物发现和开发的强大平台的潜力。
• Anti-fungal compounds
  申请人：SAINT LOUIS UNIVERSITY

  公开号：US10980754B2

  公开（公告）日：2021-04-20

  The present disclosure provides compounds of the formula (I), (II), (III), wherein the variables are as defined herein for use in the treatment of fungal infections. In some embodiments, the fungal infection is an infection of Cryptococcus neojormans fungus. Also provided herein are compositions comprising a compound of formula I, II, or III and a second anti-fungal agent.

  本公开提供了式(I)、(II)、(III)化合物，其中变量如本文所定义，用于治疗真菌感染。在某些实施方案中，真菌感染是新隐球菌真菌的感染。本文还提供了包含式 I、II 或 III 的化合物和第二种抗真菌剂的组合物。
• ANTI-FUNGAL COMPOUNDS
  申请人：SAINT LOUIS UNIVERSITY

  公开号：US20190099385A1

  公开（公告）日：2019-04-04

  The present disclosure provides compounds of the formula (I), (II), (III), wherein the variables are as defined herein for use in the treatment of fungal infections. In some embodiments, the fungal infection is an infection of Cryptococcus neojormans fungus. Also provided herein are compositions comprising a compound of formula I, II, or III and a second anti-fungal agent.
• INHIBITORS OF NUCLEOTIDYLTRANSFERASE SUPERFAMILY ENZYMES AS ANTIBIOTICS
  申请人：Saint Louis University

  公开号：US20200147086A1

  公开（公告）日：2020-05-14

  In one aspect, the present disclosure provides methods of treating a bacterial infection using an inhibitor of the nucleotidyltransferase superfamily enzyme. In some embodiments, the compounds have one of the following formulas (I), (II), (III), or (IV) wherein R 1 , R 2 , and R 3 are as defined herein or a pharmaceutically acceptable salt thereof. The compounds may be used to treat a bacterial infection including an infection of Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa , and Enterobacter species.