密胆碱 | 16478-59-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 中文名称: 密胆碱
• 英文名称: Hemicholinium
• 英文别名: 2-[4-[4-(2-hydroxy-4,4-dimethylmorpholin-4-ium-2-yl)phenyl]phenyl]-4,4-dimethylmorpholin-4-ium-2-ol
• CAS: 16478-59-4
• 化学式: C24H34N2O4+2
• 分子量: 414.5
• InChiKey: JIWUESGGKYLPPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] DIAGNOSING AND TREATING CANCER<br/>[FR] DIAGNOSTIC ET TRAITEMENT DU CANCER
  申请人：UNIV PENNSYLVANIA

  公开号：WO2014165216A1

  公开（公告）日：2014-10-09

  The invention relates to compositions and methods for diagnosing as well as treating cancer diseases associated with choline kinase (ChoK). Specifically, the invention relates to a composition comprising an intrinsically fluorescent choline kinase (ChoK) inhibitor or a ChoK inhibitor operably linked to a fluorescent dye. The composition is capable of diagnosing and/or treating cancer diseases associated with ChoK.

  本发明涉及与胆碱激酶（ChoK）相关的癌症疾病的诊断和治疗的组合物和方法。具体而言，本发明涉及一种组合物，包括本质上荧光的胆碱激酶（ChoK）抑制剂或与荧光染料操作性链接的ChoK抑制剂。该组合物能够诊断和/或治疗与ChoK相关的癌症疾病。
• Bis-Cationic Compounds and Use Thereof
  申请人：Widmer Alfred Werner

  公开号：US20080275003A1

  公开（公告）日：2008-11-06

  The present invention relates to bis-cationic compounds comprising quaternary ammonium groups and/or quaternary phosphonium groups. The invention also relates to the use of bis-cationic compounds as Phospholipase B inhibitors and the use of bis cationic compounds for the treatment or prevention of microbial infection.
• US7947854B2
  申请人：——

  公开号：US7947854B2

  公开（公告）日：2011-05-24

表征谱图