(1Z)-N',2-二羟基-2-苯基乙脒 | 24440-15-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (1Z)-N',2-二羟基-2-苯基乙脒
• 英文名称: Mandelsaeure-amidoxim
• 英文别名: (1Z)-N',2-dihydroxy-2-phenylethanimidamide；N',2-dihydroxy-2-phenylethanimidamide
• CAS: 24440-15-1
• 化学式: C₈H₁₀N₂O₂
• mdl: MFCD26935379
• 分子量: 166.18
• InChiKey: GXYVISXLFBQBKH-UHFFFAOYSA-N

物化性质

• 熔点：
  148-152℃

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  78.8
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 海关编码：
  2925290090

反应信息

• 作为反应物：
  描述：

  (1Z)-N',2-二羟基-2-苯基乙脒 、 乙酰氯 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Gross, Chemische Berichte, 1885, vol. 18, p. 1077

  摘要：

  DOI：
• 作为产物：
  描述：

  扁桃腈 在 乙醇 、 盐酸羟胺 、 水 、 sodium carbonate 作用下， 生成 (1Z)-N',2-二羟基-2-苯基乙脒
  参考文献：
  名称：

  Gross, Chemische Berichte, 1885, vol. 18, p. 1077

  摘要：

  DOI：

文献信息

• PLATINUM COMPLEXES
  申请人：Takasago International Corporation

  公开号：EP1577300A1

  公开（公告）日：2005-09-21

  The invention aims at providing platinum complexes useful as materials for light emitting devices and extremely excellent in heat stability, luminous characteristics, and luminous efficiency, and a process for effective preparation thereof. The invention relates to platinum complexes represented by the general formula [1]: wherein any two of A, B and C are each independently an optionally substituted nitrogenous aromatic heterocyclic group and the other is optionally substituted aryl or optionally substituted heteroaryl; and Y is halogeno or an optionally substituted aryl or heteroaryl group which is bonded either directly or through oxygen (-O-) or sulfur (-S-) (with the proviso that when the adjacent two rings are nitrogenous aromatic heterocyclic groups, the cases wherein Y is chloro are excepted, while when the nonadjacent two rings are nitrogenous aromatic heterocyclic groups, the cases wherein Y is not halogeno are excepted).

  该发明旨在提供作为发光器件材料有用的铂配合物，其在热稳定性、发光特性和发光效率方面极为优异，并提供了一种有效制备这些铂配合物的方法。该发明涉及由通式[1]表示的铂配合物：其中A、B和C中的任意两个分别是一个可选择取代的氮芳杂环基团，另一个是可选择取代的芳基或可选择取代的杂环基；Y是卤素或一个可选择取代的芳基或杂环基，它通过氧（-O-）或硫（-S-）直接或间接结合（但当相邻的两个环是氮芳杂环基团时，Y是氯的情况除外，而当非相邻的两个环是氮芳杂环基团时，Y不是卤素的情况除外）。
• A new oxime ligand in manganese chemistry: a [Mn8] and a [Mn6] cage from the use of 2-dihydroxy-2-phenylacetamidine
  作者：Andreas G. Flamourakis、Demetrios Tzimopoulos、Milosz Siczek、Tadeusz Lis、James R. O'Brien、Pericles D. Akrivos、Constantinos J. Milios

  DOI：10.1039/c1dt11455g

  日期：——

  The use of phamidoxH2 (phamidoxH2 = 2-dihydroxy-2-phenylacetamidine) in manganese cluster chemistry led to the synthesis and characterization of a hexametallic and an octametallic MnIII cluster, both of which display a S = 3 ground state.

  在锰簇化学中使用 phamidoxH2（phamidoxH2 = 2-二羟基-2-苯基乙脒）导致了六金属和八金属 MnIII 簇的合成和表征，这两种簇都显示出 S = 3 基态。
• Platinum complexes
  申请人：Itoh Hisanori

  公开号：US20060094875A1

  公开（公告）日：2006-05-04

  The invention aims at providing platinum complexes useful as materials for light emitting devices and extremely excellent in heat stability, luminous characteristics, and luminous efficiency, and a process for effective preparation thereof. The invention relates to platinum complexes represented by the general formula [1]: wherein any two of A, B and C are each independently an optionally substituted nitrogenous aromatic heterocyclic group and the other is optionally substituted aryl or optionally substituted heteroaryl; and Y is halogeno or an optionally substituted aryl or heteroaryl group which is bonded either directly or through oxygen (—O—) or sulfur (—S—) (with the proviso that when the adjacent two rings are nitrogenous aromatic heterocyclic groups, the cases wherein Y is chloro are excepted, while when the nonadjacent two rings are nitrogenous aromatic heterocyclic groups, the cases wherein Y is not halogeno are excepted).

  该发明旨在提供一种铂配合物，可用作发光器件材料，具有极佳的热稳定性、发光特性和发光效率，并提供一种有效的制备方法。该发明涉及由通式[1]表示的铂配合物：其中，A、B和C中的任意两个分别独立地是可选取代的氮杂芳香族环基团，另一个是可选取代的芳基或可选取代的杂芳基；Y是卤素或经过氧（—O—）或硫（—S—）直接或通过键合的可选取代的芳基或杂芳基团（但当相邻的两个环为氮杂芳香族环基团时，除了Y为氯的情况外，当非相邻的两个环为氮杂芳香族环基团时，除了Y不是卤素的情况外，都不在此限）。
• Pyrrolidine oxadiazole-and thiadiazole derivatives
  申请人：——

  公开号：US20040220238A1

  公开（公告）日：2004-11-04

  The present invention is related to pyrrolidine oxadiazole and thiadiazole derivatives for use as pharmaceutically active compounds, as well as pharmaceutical formulations containing such pyrrolidine oxadiazole derivatives. Said pyrrolidine derivatives are useful in the treatment and/or prevention of preterm labor, premature birth and dysmenorrhea. In particular, the present invention is related to pyrrolidine derivatives displaying a substantial modulatory, notably an antagonist activity of the oxytocin receptor. More preferably, said compounds are useful in the treatment and/or prevention of disease states mediated by oxytocin, including preterm labor, premature birth and dysmenorrhea. The present invention is furthermore related to novel pyrrolidine derivatives as well as to methods of their preparation. (I) B is a oxadiazole or thiadiazole group. 1

  本发明涉及吡咯烷氧二唑和噻二唑衍生物，用作药物活性化合物，以及含有此类吡咯烷氧二唑衍生物的制药配方。所述吡咯烷衍生物在治疗和/或预防早产、早产和痛经方面具有用途。特别地，本发明涉及显示出显著调节活性，特别是催产素受体拮抗剂活性的吡咯烷衍生物。更具体地，这些化合物在治疗和/或预防由催产素介导的疾病状态方面具有用途，包括早产、早产和痛经。本发明还涉及新型吡咯烷衍生物及其制备方法。(I) B是氧代二唑或噻二唑基团。
• Pyrrolidine oxadiazole-and thiadiazole oxime derivatives being oxytocin receptor antagonists
  申请人：Schwarz Matthias

  公开号：US20060229343A1

  公开（公告）日：2006-10-12

  The present invention is related to pyrrolidine oxadiazole and thiadiazole derivatives for use as pharmaceutically active compounds, as well as pharmaceutical formulations containing such pyrrolidine oxadiazole derivatives. Said pyrrolidine derivatives are useful in the treatment and/or prevention of preterm labor, premature birth and dysmenorrhea. In particular, the present invention is related to pyrrolidine derivatives displaying a substantial modulatory, notably an antagonist activity of the oxytocin receptor. More preferably, said compounds are useful in the treatment and/or prevention of disease states mediated by oxytocin, including preterm labor, premature birth and dysmenorrhea. The present invention is furthermore related to novel pyrrolidine derivatives as well as to methods of their preparation. B is a oxadiazole or thiadiazole group.

  本发明涉及吡咯烷氧噻二唑和噻二唑衍生物，用作药物活性化合物，以及包含此类吡咯烷氧噻二唑衍生物的制药配方。所述吡咯烷衍生物在治疗和/或预防早产、早产和痛经方面具有用途。特别是，本发明涉及显示出 oxytocin 受体的重要调节作用，特别是拮抗剂活性的吡咯烷衍生物。更具体地说，所述化合物在治疗和/或预防由 oxytocin 介导的疾病状态方面具有用途，包括早产、早产和痛经。本发明还涉及新的吡咯烷衍生物以及它们的制备方法。B 是一个氧噻二唑或噻二唑基团。