Lipoxin E4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Lipoxin E4
• 英文别名: (5S,6R,7E,9E,11Z,13E,15S)-6-[(2R)-2-amino-2-carboxyethyl]sulfanyl-5,15-dihydroxyicosa-7,9,11,13-tetraenoic acid
• 化学式: C₂₃H₃₇NO₆S
• 分子量: 455.6
• InChiKey: KVXVULITEYDTNN-HGCWDHQMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  31
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  166
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• Compounds and methods for modulating vascular injury
  申请人：The Regents of the University of California

  公开号：US10111847B2

  公开（公告）日：2018-10-30

  Methods of modulating healing response to vascular injury and/or vascular scarring in a subject are provided. As such, aspects of the disclosure relate to the use of pro-resolving lipid mediators to modulate inflammation and/or restenosis of a vascular wall. Another aspect of the disclosure relates to the use of pro-resolving lipid mediators to modulate a biological activity of vascular smooth muscle cells (VSMC) or vascular endothelial cells (VEC). Pro-resolving lipid mediators that fmd use in the subject methods include derivatives of omega-3 polyunsaturated fatty acids and omega-6 polyunsaturated fatty acids, such as resolvins, protectins, lipoxins and maresins and their therapeutically stable analogs. Also provided are vascular devices and compositions for use in the subject methods. Such methods, devices and compositions fmd use in a variety of applications, including applications related to treatment of vascular injuries and vascular scarring (e.g., restenosis), and applications related to chronic inflammatory diseases of the vascular wall.

  本发明提供了调节受试者血管损伤和/或血管瘢痕愈合反应的方法。因此，本公开的各个方面涉及使用促溶解脂质介质来调节血管壁的炎症和/或再狭窄。本公开的另一方面涉及使用促溶解脂质介质调节血管平滑肌细胞（VSMC）或血管内皮细胞（VEC）的生物活性。可用于上述方法的促溶解脂质介质包括欧米伽-3 多不饱和脂肪酸和欧米伽-6 多不饱和脂肪酸的衍生物，如 resolvins、protectins、lipoxins 和 maresins 及其治疗上稳定的类似物。此外，还提供了用于上述方法的血管装置和组合物。这些方法、装置和组合物可用于多种应用，包括与治疗血管损伤和血管瘢痕（如再狭窄）有关的应用，以及与血管壁慢性炎症性疾病有关的应用。
• Compounds and Methods for Modulating Vascular Injury
  申请人：The Regents of the University of California

  公开号：US20150216829A1

  公开（公告）日：2015-08-06

  Methods of modulating healing response to vascular injury and/or vascular scarring in a subject are provided. As such, aspects of the disclosure relate to the use of pro-resolving lipid mediators to modulate inflammation and/or restenosis of a vascular wall. Another aspect of the disclosure relates to the use of pro-resolving lipid mediators to modulate a biological activity of vascular smooth muscle cells (VSMC) or vascular endothelial cells (VEC). Pro-resolving lipid mediators that find use in the subject methods include derivatives of omega-3 polyunsaturated fatty acids and omega-6 polyunsaturated fatty acids, such as resolvins, protectins, lipoxins and maresins and their therapeutically stable analogs. Also provided are vascular devices and compositions for use in the subject methods. Such methods, devices and compositions find use in a variety of applications, including applications related to treatment of vascular injuries and vascular scarring (e.g., restenosis), and applications related to chronic inflammatory diseases of the vascular wall.
• US9463177B2
  申请人：——

  公开号：US9463177B2

  公开（公告）日：2016-10-11