(2R,3R)-3-膦酰氧基-2-(7-硫基庚酰氨基)丁酸 | 104302-77-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: (2R,3R)-3-膦酰氧基-2-(7-硫基庚酰氨基)丁酸
• 中文别名: 7-巯基庚酰苏氨酸磷酸酯
• 英文名称: coenzyme B
• 英文别名: (2S,3R)-3-phosphonooxy-2-(7-sulfanylheptanoylamino)butanoic acid
• CAS: 104302-77-4
• 化学式: C₁₁H₂₂NO₇PS
• 分子量: 343.34
• InChiKey: JBJSVEVEEGOEBZ-SCZZXKLOSA-N

物化性质

• 密度：
  1.367±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  21
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  134
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• BIOLOGICAL SYNTHESIS OF DIFUNCTIONAL ALKANES FROM CARBOHYDRATE FEEDSTOCKS
  申请人：Baynes Brian M.

  公开号：US20120164702A1

  公开（公告）日：2012-06-28

  Aspects of the invention relate to methods for the production of difunctional alkanes in host cells. In particular, aspects of the invention describe components of genes associated with the difunctional alkane production from carbohydrate feedstocks in host cells. More specifically, aspects of the invention describe metabolic pathways for the production of adipic acid, aminocaproic acid, caprolactam, and hexamethylenediamine via 2-ketopimelic acid.

  本发明涉及在宿主细胞中生产双官能基烷烃的方法。具体而言，本发明描述了与从碳水化合物饲料中在宿主细胞中生产双官能基烷烃相关的基因组成部分。更具体地，本发明描述了通过2-酮基戊二酸生产己二酸、氨基己酸、己内酰胺和六亚甲基二胺的代谢途径。
• Biological Synthesis of Difunctional Alkanes from Carbohydrate Feedstocks
  申请人：Baynes Brian M.

  公开号：US20100151536A1

  公开（公告）日：2010-06-17

  Aspects of the invention relate to methods for the production of difunctional alkanes in host cells. In particular, aspects of the invention describe components of genes associated with the difunctional alkane production from carbohydrate feedstocks in host cells. More specifically, aspects of the invention describe metabolic pathways for the production of adipic acid, aminocaproic acid, caprolactam, and hexamethylenediamine via 2-ketopimelic acid.

  本发明涉及在宿主细胞中生产双官能基烷烃的方法。具体而言，本发明涉及与从碳水化合物饲料中生产双官能基烷烃相关的基因组成部分。更具体地，本发明涉及通过2-酮基戊二酸生产己二酸、氨基己酸、己内酰胺和六亚甲基二胺的代谢途径。
• BIOCONVERSION PROCESS FOR PRODUCING NYLON-7, NYLON-7,7 AND POLYESTERS
  申请人：INVISTA TECHNOLOGIES S.a.r.l.

  公开号：US20150337275A1

  公开（公告）日：2015-11-26

  Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional C7 alkanes are useful as intermediates in the production of nylon-7, nylon-7,x, nylon-x,7, and polyesters.

  本发明实施例涉及在分离酶存在或在表达这些酶的重组宿主细胞存在下，生物合成双或三功能C7烷的方法。这些双或三功能C7烷在生产尼龙-7、尼龙-7，x、尼龙-x，7和聚酯中作为中间体是有用的。
• Methane oxidation methods and compositions
  申请人：California Institute of Technology

  公开号：US10011813B2

  公开（公告）日：2018-07-03

  The disclosure provides devices and methods to produce electrical energy from microorganisms capable of metabolizing methane.

  本公开提供了利用能够代谢甲烷的微生物生产电能的装置和方法。
• Inhibition of methanogenesis to control wood boring insects and pestilence
  申请人：Environmental Intellectual Property, Inc

  公开号：US10219518B2

  公开（公告）日：2019-03-05

  A method for inhibiting methane production in the digestive tract of methanogenic Archaea (e.g., termites, other wood boring pests). The inhibiting of the critical biochemical pathways specific to the methanogenic Archaea is achieved by having the methanogenic Archaea ingest an anti-methanogenic compound. The anti-methanogenic compound may include, for example, naturally-occurring statins or derivatives thereof, linoleic acid or related compounds, essential oils, or some combination thereof. The naturally-occurring statins can be found in the red yeast rice extract or related biomass. As a result, the effectiveness of the methanogenic Archaea to produce methane is compromised, which subsequently results into the malfunctioning of the xylophages' digestive system. This provides a safe, natural, green and sustainable means of controlling many pests such as the Asian Beetle, Emerald Ash borer, Weevils, Deathwatch Caterpillars, and termites.

  一种抑制产甲烷古细菌（如白蚁、其他钻木害虫）消化道产甲烷的方法。通过让产甲烷古细菌摄入一种抗产甲烷化合物来抑制产甲烷古细菌特有的关键生化途径。例如，抗甲烷生成化合物可包括天然存在的他汀类药物或其衍生物、亚油酸或相关化合物、精油或它们的某些组合。天然他汀类物质可以在红麴提取物或相关生物质中找到。因此，产甲烷古细菌产生甲烷的效果会受到影响，进而导致木虱消化系统失灵。这为控制亚洲甲虫、翡翠灰螟、象鼻虫、死亡守望毛虫和白蚁等许多害虫提供了一种安全、天然、绿色和可持续的方法。