(2R,3S,4R,5R)-2,3,4,5,6-五羟基-N-(2-巯基乙基)己酰胺 | 3786-84-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: (2R,3S,4R,5R)-2,3,4,5,6-五羟基-N-(2-巯基乙基)己酰胺
• 英文名称: 2-gluconamidoethyl thiol
• 英文别名: N-(2-mercaptoethyl) gluconamide；N-(2-mercaptoethyl)-gluconamide；N-(2-Mercaptoethyl)gluconamide；(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxy-N-(2-sulfanylethyl)hexanamide
• CAS: 3786-84-3
• 化学式: C₈H₁₇NO₆S
• 分子量: 255.292
• InChiKey: REIFAYOWRIOBDG-MVIOUDGNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.3
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  131
• 氢给体数：
  7
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (2R,3S,4R,5R)-2,3,4,5,6-五羟基-N-(2-巯基乙基)己酰胺 、 二氯(DPPE)二金(I) 在 三乙胺 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 3.0h， 以69%的产率得到
  参考文献：
  名称：

  Synthesis, characterization and anticancer evaluation of phosphinogold(I) thiocarbohydrate complexes

  摘要：

  Several novel thiocarbohydrate phosphinogold(I) complexes were prepared via the reaction of n-gluconamidoalkyl thiol (Ll-L7) (where L1 -L4 = n-gluconamidoalkyl thiol (n = 1-4), L5 L7 = acetylated n-gluconamidoalkyl thiol (n = 1-3)) with the gold precursors [AuCl(PPh3)], [Au2Cl2(dppe)], [Au2Cl2(dPPP)] and [Au2Cl2(dppb)], leading to the new gold(I) complexes [Au(L1) (PPh3)] (1-4), [Au(L5)(PPh3)] (5-7), IAu2(L1)(2)(dPPe)1 (8-11), (Au-2(L5)(2)(dPPx)1 (L2-14), [(Au-2(L6)(2)) (dppx)] (15-17), [Au-2(L7)(2)(dPPx)] (18-20), {where dppe= 1,2-bis(diphenylphosphino)ethane (x = e), dppp = 1,3-bis(diphenylphosphino)propane (x = p) and dppb = 1,4-bis-(diphenylphosphino)butane (x = b)). These gold complexes were characterized by a combination of NMR and infrared spectroscopy, microanalysis and mass spectrometry. Complexes 8,12,14-16 (IC50 values between 0.003 and 1.8 p.M) are all active against MCF7, HCT116 and PO cells. Complex 8 recorded the highest IC50 value of 0.003 mu M against PO. Complex 14 was found to be selective towards both MCF7 and PC3 cells with a TS value of 142.1, while compounds 15 and 16 were highly selective toward PO cells with TS values of 970.0 and 937.5, respectively. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2017.09.010

文献信息

• [EN] METHODS FOR THE TREATMENT OF CYSTEAMINE SENSITIVE DISORDERS<br/>[FR] MÉTHODES DE TRAITEMENT DES TROUBLES SENSIBLES À LA CYSTÉAMINE
  申请人：THIOGENESIS THERAPEUTICS INC

  公开号：WO2019060634A1

  公开（公告）日：2019-03-28

  The invention features methods for the treatment of cystinosis and other cysteamine sensitive disorders in a subject including administration of a disulfide convertible to cysteamine in vivo. The methods can include the separate administration of a reducing agent to the subject to increase the bioavailablity and extend the plasma pharmacokinetic profile of the cysteamine produced following administration of the disulfide. The methods permit sustained cysteamine plasma concentrations in a subject.

  这项发明涉及治疗囊性氨基酸病和其他对半胱氨酸敏感的疾病的方法，包括在体内给予可转化为半胱氨酸的二硫化物。该方法可以包括向受试者单独给予还原剂，以增加半胱氨酸在给予二硫化物后产生的生物利用度，并延长血浆药代动力学特性。该方法允许受试者体内维持持续的半胱氨酸血浆浓度。
• Dithiols comprising at least one amide functional group and their use in transforming the shape of the hair
  申请人：Philippe Michel

  公开号：US20050002886A1

  公开（公告）日：2005-01-06

  An embodiment disclosed herein is the use in cosmetics of at least one dithiol comprising an amide functional group for transforming the shape of the hair. Also disclosed herein are cosmetic compositions comprising at least one dithiol comprising an amide functional group in a cosmetically acceptable medium.

  本公开的一种实施例是在化妆品中使用至少一种含有酰胺官能团的二硫醇来改变头发的形状。本公开还涉及包含至少一种含有酰胺官能团的二硫醇的化妆品组合物，其中所述组合物在化妆学上可接受的介质中。
• Curly hair-straightening composition comprising keratin reducing substances and alcohols
  申请人：KAO CORPORATION

  公开号：EP0658338A1

  公开（公告）日：1995-06-21

  A curly hair-straightening composition is disclosed, which comprises: (A) from 1 to 20 % by weight of one or more keratin-reducing substances selected from the group consisting of thioglycolic acid, thioglycolic acid derivatives, cysteine, N-acylcysteines, salts thereof, thioglyceryl alkyl ethers, mercaptoalkylamides, sulfites and hydrogensulfites; (B) one or more alcohols selected from the group consisting of monohydric alcohols having a straight-chain or branched alkyl group carrying 3 or 4 carbon atoms and dihydric or trihydric alcohols having a straight-chain or branched alkyl group having 4 to 6 carbon atoms; and (C) water; wherein the weight ratio of the component (B) to the component (C) is from 1:3 to 3:1. Further, a method for straightening curly hair by using this composition is also disclosed. The curly hair-straightening composition of the present invention can permanently and sufficiently straighten natural curly hair or frizzy hair without causing any damage on the hair.

  本发明公开了一种卷发拉直组合物，其中包括(A) 1%至 20%（按重量计）的一种或多种角蛋白还原物质，这些物质选自由 硫代乙醇酸、硫代乙醇酸衍生物、半胱氨酸、N-酰半胱氨酸、其盐、硫代 甘油烷基醚、巯基烷基酰胺、亚硫酸盐和亚硫酸氢盐组成的组；(B) 一种或多种醇，选自由含 3 或 4 个碳原子的直链或支链烷基的一元醇和含 4 至 6 个碳原子的直链或支链烷基的二元或三元醇组成的组；以及 (C) 水；其中组分 (B) 与组分 (C) 的重量比为 1：3 至 3:1。此外，还公开了一种使用该组合物拉直卷发的方法。本发明的卷发拉直组合物可以永久、充分地拉直自然卷发或毛躁的头发，而不会对头发造成任何损伤。
• Hair cosmetic composition
  申请人：Kao Corporation

  公开号：EP0784970A2

  公开（公告）日：1997-07-23

  A hair cosmetic composition contains an oxyalkylenized xanthan gum in combination with at least one component selected from an oxidizing agent, a reducing agent, a film-forming polymer, an oxidation dye or an acid dye.

  一种头发化妆品组合物含有氧烷基化黄原胶与至少一种选自氧化剂、还原剂、成膜聚合物、氧化染料或酸性染料的成分。
• HAIR STYLE CONTROL AGENT
  申请人：KAO CORPORATION

  公开号：EP1752130A1

  公开（公告）日：2007-02-14

  A first hair style control agent containing: (A) a keratin-reducing substance, (B) a guanidine derivative represented by the general formula (1): wherein R1 represents a linear or branched alkyl group having 6 to 12 carbon atoms, or an acid addition salt thereof, and (C) a nonionic surfactant represented by the general formula (2): wherein R2 represents a linear or branched alkyl group having 8 to 18 carbon atoms, and n represents an integer of 1 to 25. The first hair style control agent of the present invention may permanently straighten naturally curly/unruly hair, without damaging or providing a dry feeling to the hair.

  第一种发型控制剂，含有 (A) 一种角蛋白还原物质、 (B) 由通式(1)代表的胍衍生物： 其中 R1 代表具有 6 至 12 个碳原子的直链或支链烷基，或其酸加成盐，以及 (C) 由通式(2)表示的非离子表面活性剂： 其中 R2 代表具有 8 至 18 个碳原子的直链或支链烷基，n 代表 1 至 25 的整数。本发明的第一种发型控制剂可以永久拉直自然卷曲/乱蓬蓬的头发，而不会损伤头发或给头发带来干燥感。