(2S)-2-氨基-5-[[(2R)-1-(羧甲基氨基)-3-(2-氯乙基氨基甲酰硫基)-1-氧代丙烷-2-基]氨基]-5-氧代戊酸 | 38134-58-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: (2S)-2-氨基-5-[[(2R)-1-(羧甲基氨基)-3-(2-氯乙基氨基甲酰硫基)-1-氧代丙烷-2-基]氨基]-5-氧代戊酸
• 英文名称: S-((2-Chloroethyl)carbamoyl)glutathione
• 英文别名: (2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-3-(2-chloroethylcarbamoylsulfanyl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
• CAS: 38134-58-6
• 化学式: C₁₃H₂₁ClN₄O₇S
• 分子量: 412.85
• InChiKey: BXPMYWSZMJXCHC-YUMQZZPRSA-N

物化性质

• 密度：
  1.4496 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.9
• 重原子数：
  26
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  213
• 氢给体数：
  6
• 氢受体数：
  9

制备方法与用途

类别：有毒物质

可燃性危险特性：

• 可燃；火场分解产生有毒氯化物、硫氧化物及氮氧化物气体。

储运特性：

• 库房应保持低温、通风且干燥。

灭火剂：

• 水、二氧化碳、干粉或砂土均可用于灭火。

文献信息

• METHODS FOR THE EFFECTIVE TREATMENT OF METASTATIC CANCER
  申请人：Glazier, Arnold

  公开号：EP3388060A1

  公开（公告）日：2018-10-17

  The present invention relates to methods for the treatment of metastatic cancer. Methods of treating metastatic cancer by administration of a set of drugs overcome multiple mechanisms of melphalan resistance and hypersensitize cancer cells to melphalan are described. The methods involve the administration of drug(s) that induce oxidative stress in cancer cells, in conjunction with melphalan on a defined schedule.

  本发明涉及治疗转移性癌症的方法。本发明描述了通过给药克服美法仑抗药性的多种机制并使癌细胞对美法仑过敏来治疗转移性癌症的方法。这些方法包括在美法仑的同时，按规定的时间表服用诱导癌细胞氧化应激的药物。
• Combination therapy for metastatic cancer
  申请人：General Oncology, Inc.

  公开号：US11154520B2

  公开（公告）日：2021-10-26

  The present invention relates to methods and sets of drugs for the effective treatment of metastatic cancer and the administration of a set of drugs that overcome mechanisms of resistance to DNA-damaging agents, thereby sensitizing cancer cells to said DNA-damaging agents. The methods involve the administration of a set of drugs comprising melphalan, BCNU, hydroxocobalamin, and ascorbic acid. In a preferred embodiment, ethanol is also added to the set of drugs and bone marrow toxicity is reversed with an infusion of bone marrow stem cells. The methods also involve the depletion of GSH in tumors and the selective delivery of drugs to solid tumors. The methods also involve preventing the loss of catalase function and preventing oxidant-induced hemolysis and/or methemoglobin formation in subjects treated with oxidant drugs or agents that generate hydrogen peroxide, wherein said methods comprise the systemic administration of ethanol.

  本发明涉及有效治疗转移性癌症的方法和成套药物，以及服用能克服对DNA损伤剂的抗药性机制的成套药物，从而使癌细胞对所述DNA损伤剂敏感。这些方法包括服用由美法仑、BCNU、羟钴胺和抗坏血酸组成的一组药物。在一个优选的实施方案中，乙醇也被添加到这套药物中，并通过输注骨髓干细胞来逆转骨髓毒性。这些方法还包括消耗肿瘤中的 GSH 以及选择性地向实体瘤输送药物。这些方法还涉及防止过氧化氢酶功能的丧失，以及防止氧化剂诱导的溶血和/或高铁血红蛋白的形成，受试者使用氧化剂药物或产生过氧化氢的制剂治疗，其中所述方法包括全身给药乙醇。
• EP2908809A2
  申请人：——

  公开号：EP2908809A2

  公开（公告）日：2015-08-26
• COMBINATION FOR THE EFFECTIVE TREATMENT OF METASTATIC CANCER IN PATIENTS
  申请人：General Oncology, Inc.

  公开号：EP3386546A1

  公开（公告）日：2018-10-17
• Methods for the Effective Treatment of Metastatic Cancer
  申请人：GLAZIER Arnold

  公开号：US20150265641A1

  公开（公告）日：2015-09-24

  The present invention relates to methods for the treatment of metastatic cancer. Methods of treating metastatic cancer by administration of a set of drugs overcome multiple mechanisms of melphalan resistance and hypersensitize cancer cells to melphalan are described. The methods involve the administration of drug(s) that induce oxidative stress in cancer cells, in conjunction with melphalan on a defined schedule.