(2S,4R)-1,4-二甲基吡咯烷-2-羧酸 | 1946010-81-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: (2S,4R)-1,4-二甲基吡咯烷-2-羧酸
• 英文名称: (2S,4R)-1,4-Dimethylpyrrolidine-2-carboxylic acid
• CAS: 1946010-81-6
• 化学式: C₇H₁₃NO₂
• 分子量: 143.18
• InChiKey: FAKNQOZVXKYTPZ-RITPCOANSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] SUBSTITUTED UREA DEPSIPEPTIDE ANALOGS AS ACTIVATORS OF THE CLPP ENDOPEPTIDASE<br/>[FR] ANALOGUES DE DEPSIPEPTIDE D'URÉE SUBSTITUÉS À UTILISER EN TANT QU'ACTIVATEURS DE L'ENDOPEPTIDASE CLPP
  申请人：ST JUDE CHILDRENS RES HOSPITAL

  公开号：WO2018045313A1

  公开（公告）日：2018-03-08

  In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  在一个方面，本发明涉及替代脲depsipeptide类似物，其衍生物以及相关化合物，这些化合物可用作激活ClpP内肽酶的活化剂；制备这些化合物的合成方法；包含这些化合物的药物组合物；以及使用这些化合物和组合物治疗传染病的方法。本摘要旨在作为在特定领域进行搜索的扫描工具，并不意味着对本发明的限制。
• Dihydrothienopyrimidines for the Treatment of Inflammatory Diseases
  申请人：Pouzet Pascale

  公开号：US20080096882A1

  公开（公告）日：2008-04-24

  The invention relates to new dihydrothienopyrimidine of formula 1, as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, wherein X is SO or SO 2 , but preferably SO, and wherein R 1 , R 2 and R 3 have the meanings given in the description, and which are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system or cancers, as well as pharmaceutical compositions which contain these compounds.

  该发明涉及公式1的新二氢噻吡嘧啶，以及其药理学上可接受的盐、对映体、旋光异构体、消旋体、水合物或溶剂合物，其中X为SO或SO2，但最好为SO，R1、R2和R3在描述中给出的含义，并且适用于治疗呼吸道或胃肠道疾病、关节、皮肤或眼睛的炎症性疾病、外周或中枢神经系统疾病或癌症，以及含有这些化合物的药物组合物。
• HEPATITIS C VIRUS INHIBITORS
  申请人：Bachand Carol

  公开号：US20090068140A1

  公开（公告）日：2009-03-12

  The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

  本公开涉及化合物、组合物和治疗丙型肝炎病毒（HCV）感染的方法。还揭示了含有这些化合物的制药组合物和使用这些化合物治疗HCV感染的方法。
• Dihydrothienopyrimidines for the treatment of inflammatory Diseases
  申请人：POUZET Pascale

  公开号：US20120108534A1

  公开（公告）日：2012-05-03

  The invention relates to new dihydrothienopyrimidine of formula 1 , as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, wherein X is SO or SO 2 , but preferably SO, and wherein R 1 , R 2 and R 3 have the meanings given in the description, and which are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system or cancers, as well as pharmaceutical compositions which contain these compounds.

  本发明涉及一种新的二氢噻唑嘧啶化合物，其化学式为1，以及其药物学上可接受的盐、对映异构体、对映体、外消旋体、水合物或溶剂化物，其中X为SO或SO2，但优选为SO，R1、R2和R3在说明中给出了其含义，该化合物适用于治疗呼吸或胃肠道不适或疾病、关节、皮肤或眼睛的炎症性疾病、周围或中枢神经系统疾病或癌症，以及含有这些化合物的制药组合物。
• CONFORMATIONALLY RESTRICTED BIPHENYL DERIVATIVES FOR USE AS HEPATITIS C VIRUS INHIBITORS
  申请人：Bristol-Myers Squibb Company

  公开号：EP2242750B1

  公开（公告）日：2013-04-24