N-[(E)-butan-2-ylideneamino]acetamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[(E)-butan-2-ylideneamino]acetamide
• 化学式: C₆H₁₂N₂O
• 分子量: 128.17
• InChiKey: SYBJGNZMJSFXHF-FNORWQNLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] DRUG-PROTEIN CONJUGATES<br/>[FR] CONJUGUÉS MÉDICAMENT-PROTÉINE
  申请人：POLYTHERICS LTD

  公开号：WO2014064423A1

  公开（公告）日：2014-05-01

  Specific conjugates containing auristatins and a binding protein or peptide, and processes for making them, are described. The conjugates use specific linker technology which gives advantages over known antibody-drug conjugates. Also described are specific conjugates of drugs and a binding protein or peptide in which more than one copy of the drug is present.

  包含奥利司他汀和结合蛋白或肽的特定共轭物以及制备它们的过程被描述。这些共轭物使用特定的连接技术，相比已知的抗体药物共轭物具有优势。还描述了药物和结合蛋白或肽的特定共轭物，其中药物的副本超过一个。
• CHEMOSELECTIVE LIGATION
  申请人：Saxon Eliana

  公开号：US20110236930A1

  公开（公告）日：2011-09-29

  The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between the two reactive partners resulting in a final product comprising a phosphine moiety, or which can be engineered to comprise a cleavable linker so that a substituent of the phosphine is transferred to the azide, releasing an oxidized phosphine byproduct and producing a native amide bond in the final product. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).

  本发明涉及一种可以在生理条件下进行的化学选择性连接反应。一般来说，本发明涉及特别设计的膦化合物的缩合，该膦化合物可以提供在两个反应物之间形成酰胺键，从而产生包含膦基团的最终产物，或者可以被设计为包含可断裂的连接器，以便将膦的取代基转移到偶氮化物上，释放出氧化的膦副产物并在最终产物中产生天然的酰胺键。该反应的选择性及其与水相环境的兼容性使其适用于体内（例如，细胞表面或细胞内）和体外（例如，合成肽和其他聚合物，生产修饰的（例如，标记的）氨基酸）。
• CYTOTOXIC-DRUG DELIVERING MOLECULES TARGETING HIV (CDM-HS), CYTOTOXIC ACTIVITY AGAINST THE HUMAN IMMUNODEFICIENCY VIRUS AND METHODS OF USE
  申请人：YALE UNIVERSITY

  公开号：US20150087609A1

  公开（公告）日：2015-03-26

  The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as CDM-Hs, function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by introducing cytotoxic moieties to gp120-expressing cells, thereby causing cell death and preventing cell infection and spread of HIV. It is shown that CDM-Hs bind to gp120 and gp-120 expressing cells competitively with CD4, and these compounds cause cell death of HIV-infected cells, thereby decreasing viral infectivity. Compounds and methods are described herein.
• US9745334B2
  申请人：——

  公开号：US9745334B2

  公开（公告）日：2017-08-29