(4-甲氧基-2-硝基苯基)-三甲基锡烷 | 269066-76-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (4-甲氧基-2-硝基苯基)-三甲基锡烷
• 英文名称: trimethyl(4-methoxy-2-nitrophenyl)stannane
• 英文别名: Stannane, (4-methoxy-2-nitrophenyl)trimethyl-；(4-methoxy-2-nitrophenyl)-trimethylstannane
• CAS: 269066-76-4
• 化学式: C₁₀H₁₅NO₃Sn
• 分子量: 315.944
• InChiKey: SBHXXTKGQFHBPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.15
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (4-甲氧基-2-硝基苯基)-三甲基锡烷 在 四(三苯基膦)钯 、 溶剂黄146 、 copper(I) bromide 、 锌 作用下， 以 四氢呋喃 为溶剂， 生成 2-methoxyphenanthridine
  参考文献：
  名称：

  硝基芳基锡烷类作为合成子，用于制备菲啶和苯并[i]菲啶衍生物。

  摘要：

  DOI：

  10.1021/jo991318g

文献信息

• Heterocyclic cytotoxic agents
  申请人：——

  公开号：US20030100560A1

  公开（公告）日：2003-05-29

  The invention provides compounds of formula I: 1 wherein R 1 -R 8 and A-G have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating cancer using compounds of formula I.

  这项发明提供了公式I的化合物：其中R1-R8和A-G具有规范中定义的任何含义及其药学上可接受的盐。该发明还提供了包含公式I化合物的药物组合物，用于制备公式I化合物的工艺，用于制备公式I化合物的有用中间体，以及使用公式I化合物治疗癌症的治疗方法。
• 2,3-Dimethoxybenzo[i]phenanthridines: topoisomerase I-targeting anticancer agents
  作者：Dajie Li、Baoping Zhao、Sai-Peng Sim、Tsai-Kun Li、Angela Liu、Leroy F Liu、Edmond J LaVoie

  DOI：10.1016/s0968-0896(02)00530-8

  日期：2003.2

  Appropriately substituted benzo[i]phenanthridines structurally related to nitidine, a benzo[c]phenanthridine alkaloid with antitumor activity, are active as topoisomerase 1-targeting agents. Studies on benzo[i]phenanthridines have indicated analogues that possess a 2,3-methylenedioxy moiety and at least one and preferably two methoxyl groups at the 8- and 9-positions, such as 8,9-dimethoxy-2,3-methylenedioxybenzo[i]phenanthridine, 2, are active as topoisomerase 1-targeting agents. Tetramethoxylated benzo[i]phenanthridines, wherein the 2,3-methylenedioxy moiety is replaced with methoxyl groups at the 2- and 3-position, are inactive as a topoisomerase 1-targeting agent. These results initially suggested that the 2,3-methylenedioxy moiety was critical to the retention of potent activity. Further studies revealed that 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine, 7a, is more potent than 2 as a topoisomerase 1-targeting agent. The observation that 2,3-dimethoxylated benzo[i]phenanthridines can actually exhibit enhanced activity prompted the present study in which several 8-substituted 2,3-dimethoxybenzo[i]phenanthridines were prepared and their pharmacological activities evaluated. The influence of NH2, CN, CH2OH, OBn, OCH3, OH, and NHCOCH3 substituents at the 8-position on the relative activity of these 2,3 -dimethoxybenzo[i]phenanthridines was examined. Relative to these derivatives, 7a was the most potent topoisomerase I-targeting agent, possessing similar cytotoxicity to that of nitidine in the human lymphoblast tumor cell line, RPMI8402. (C) 2002 Elsevier Science Ltd. All rights reserved.
• Nitroarylstannanes as Synthons for the Preparation of Phenanthridine and Benzo[<i>i</i>]phenanthridine Derivatives
  作者：Dajie Li、Baoping Zhao、Edmond J. LaVoie

  DOI：10.1021/jo991318g

  日期：2000.5.1