4-(4-methoxyphenyl)-N-[(E)-[(E)-3-phenylprop-2-enylidene]amino]-1,3-thiazol-2-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(4-methoxyphenyl)-N-[(E)-[(E)-3-phenylprop-2-enylidene]amino]-1,3-thiazol-2-amine
• 化学式: C₁₉H₁₇N₃OS
• 分子量: 335.4
• InChiKey: CAHQCGPCKFPSGB-IYYWNBDZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  74.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• NOVEL CHEMICAL COMPOUNDS AND THE USES THEREOF AS A MEDICINE
  申请人：Chaimbault Corinne

  公开号：US20090203747A1

  公开（公告）日：2009-08-13

  The present invention relates to the field of pharmacy, especially the treatment of neurodegenerative diseases. The invention specifically relates to a family of chemical compounds for which a neuroprotective activity has been demonstrated. Given that certain members of said family are novel compounds which have never been described, the invention relates to said novel products, the synthesis method thereof and certain novel intermediate synthesis products. The present invention further relates to compositions comprising the compounds of said family, and the use of said compounds as medicaments, especially for the preparation of a medicament for the treatment of neurodegenerative diseases.

  本发明涉及制药领域，特别是神经退行性疾病的治疗。该发明特别涉及一类化合物家族，其具有神经保护活性。鉴于该家族中的某些成员是以前未曾描述的新化合物，因此本发明涉及这些新产品，其合成方法及某些新的中间合成产物。本发明进一步涉及包含该家族化合物的组合物，以及将该化合物用作药物，特别是用于制备治疗神经退行性疾病的药物。