eptidemnamide | 949143-50-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: eptidemnamide
• 英文别名: 2-[(3S,6S,12S,21S,24S)-21-(3-amino-3-oxopropyl)-12-[3-(diaminomethylideneamino)propyl]-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17,20,23-octaoxo-1,4,7,10,13,16,19,22-octazabicyclo[22.3.0]heptacosan-6-yl]acetic acid
• CAS: 949143-50-4
• 化学式: C₃₇H₅₁N₁₃O₁₁
• 分子量: 853.892
• InChiKey: ONMUUTHWFFIREX-LROMGURASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.4
• 重原子数：
  61
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.49
• 拓扑面积：
  385
• 氢给体数：
  12
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  QGGRGDWPAYDGE 在 滴滴涕 、 PatG 、 calcium chloride 作用下， 生成 eptidemnamide
  参考文献：
  名称：

  Circular Logic: Nonribosomal Peptide-like Macrocyclization with a Ribosomal Peptide Catalyst

  摘要：

  A protease from ribosomal peptide biosynthesis macrocyclizes diverse substrates, including those resembling nonribosomal peptide and hybrid polyketide-peptide products. The proposed mechanism is analogous to thioesterase-catalyzed chemistry, but the substrates are amide bonds rather than thioesters.

  DOI：

  10.1021/ja1067806

文献信息

• Lee, Jaeheon; Mcintosh, John; Hathaway, Brian J., <hi>Journal of the American Chemical Society</hi>, <hi>2009</hi>, vol. 131, p. 2122 - 2124
  作者：Lee, Jaeheon、Mcintosh, John、Hathaway, Brian J.、Schmidt, Eric W.

  DOI：——

  日期：——
• METHODS AND COMPOSITIONS RELATED TO CYCLIC PEPTIDE SYNTHESIS
  申请人：The University of Utah Research Foundation

  公开号：EP1998792B1

  公开（公告）日：2015-02-18
• Methods and Compositions Related to Cyclic Peptide Synthesis
  申请人：University of Utah Research Foundation

  公开号：US20160326217A1

  公开（公告）日：2016-11-10

  Disclosed are compositions and methods for cyclization of polymers such as peptides.
• Circular Logic: Nonribosomal Peptide-like Macrocyclization with a Ribosomal Peptide Catalyst
  作者：John A. McIntosh、Charles R. Robertson、Vinayak Agarwal、Satish K. Nair、Grzegorz W. Bulaj、Eric W. Schmidt

  DOI：10.1021/ja1067806

  日期：2010.11.10

  A protease from ribosomal peptide biosynthesis macrocyclizes diverse substrates, including those resembling nonribosomal peptide and hybrid polyketide-peptide products. The proposed mechanism is analogous to thioesterase-catalyzed chemistry, but the substrates are amide bonds rather than thioesters.