(8alpha,9R)-6'-甲氧基辛可宁-9-醇二氢溴酸盐 | 549-47-3

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 金鸡纳生物碱
• 中文名称: (8alpha,9R)-6'-甲氧基辛可宁-9-醇二氢溴酸盐
• 英文名称: Quinine dihydrobromide
• 英文别名: (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;dihydrobromide
• CAS: 549-47-3
• 化学式: C20H26Br2N2O2
• 分子量: 486.2
• InChiKey: GKRXTXTYZVRRAI-HZQSTTLBSA-N

物化性质

• 密度：
  1.53 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  4.33
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  45.6
• 氢给体数：
  3
• 氢受体数：
  4

安全信息

• 危险等级：
  6.1(b)
• 危险品运输编号：
  UN 1544

文献信息

• Sulfamoyl sulfonate prodrugs
  申请人：Wyrwa Ralf

  公开号：US20070135375A1

  公开（公告）日：2007-06-14

  The invention relates to sulfamoyl sulfonate prodrugs of general formula I, a process for their production, pharmaceutical compositions that contain these compounds, and their use for the production of orally available pharmaceutical agents. The compounds according to the invention bind to carbonic anhydrases and inhibit these enzymes.

  本发明涉及一类通式I的磺酰胺磺酸酯前药，其生产方法，包含这些化合物的药物组合物，以及它们用于生产口服可用药物剂的应用。根据发明的化合物能与碳酸酐酶结合并抑制这些酶。
• Heteroaromatic sulphonamide prodrugs
  申请人：Wyrwa Ralf

  公开号：US20070135399A1

  公开（公告）日：2007-06-14

  The invention relates to sulphonamide prodrugs of the general formula I, having a heteroaromatic linker, to a process for their preparation, to pharmaceutical compositions comprising these compounds and to their use for the production of orally available medicaments. The compounds according to the invention bind to carboanhydrases and inhibit these enzymes.

  该发明涉及一般式I的磺胺前药，具有杂芳链，以及它们的制备方法，包含这些化合物的药物组合物，以及它们用于制备口服药物的用途。根据该发明的化合物结合到碳酸酐酶并抑制这些酶。
• Technology for the Preparation of Microparticles
  申请人：Malakhov Michael

  公开号：US20090098207A1

  公开（公告）日：2009-04-16

  Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.

  微球是通过将溶液中的大分子或小分子与抗溶剂和对离子接触，并冷却溶液而制备的。这些微球可用于制备具有明确定义尺寸的药物、营养保健品、化妆品等产品。
• Compositions and methods to effect the release profile in the transdermal administration of active agents
  申请人：——

  公开号：US20020004065A1

  公开（公告）日：2002-01-10

  Compositions and methods for the transdermal delivery of active agents up to a period of seven days or more at substantially a zero-order release rate comprising a pharmaceutically acceptable adhesive matrix and a polymeric plastic material that provides a release rate regulating effect on the active agents.

  本发明涉及一种用于经皮递送活性药剂的组合物和方法，该组合物和方法能够在持续时间为七天或更长时间内以几乎零阶释放速率递送活性药剂，包括一种药学上可接受的粘合基质和一种聚合物塑料材料，该聚合物塑料材料对活性药剂具有释放速率调节作用。
• Transdermal drug delivery device including an occlusive backing
  申请人：Noven Pharmaceuticals, Inc.

  公开号：US10231938B2

  公开（公告）日：2019-03-19

  A transdermal drug delivery system for the topical application of one or more active agents contained in one or more polymeric and/or adhesive carrier layers, proximate to a non-drug containing polymeric backing layer which can control the delivery rate and profile of the transdermal drug delivery system by adjusting the moisture vapor transmission rate of the polymeric backing layer.

  一种透皮给药系统，用于局部应用一种或多种活性剂，这些活性剂包含在一个或多个聚合物和/或粘合剂载体层中，靠近一个不含药物的聚合物背层，该背层可通过调节聚合物背层的湿气透过率来控制透皮给药系统的给药速率和概况。