(9CI)-n-1H-苯并咪唑-2-基-n-甲基-脲 | 21035-25-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 中文名称: (9CI)-n-1H-苯并咪唑-2-基-n-甲基-脲
• 英文名称: N-Methyl-N'-benzimidazolyl-harnstoff
• 英文别名: 1-(1H-benzoimidazol-2-yl)-3-methyl-urea；2-methylcarbamoylamino-benzimidazole；1-(2-Benzimidazolyl)-3-methylurea；1-(1H-benzimidazol-2-yl)-3-methylurea
• CAS: 21035-25-6
• 化学式: C₉H₁₀N₄O
• 分子量: 190.205
• InChiKey: NLWPIMXWKFZVJT-UHFFFAOYSA-N

物化性质

• 沸点：
  325.7°C (rough estimate)
• 密度：
  1.2230 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  69.8
• 氢给体数：
  3
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

制备方法与用途

类别：有毒物品

毒性分级：高毒

急性毒性：静脉-小鼠 LD50: 56 毫克/公斤

可燃性危险特性：可燃；燃烧时释放有毒氮氧化物烟雾

储运特性：通风、低温干燥；与库房食品原料分开存放

灭火剂：二氧化碳、泡沫、砂土、雾状水

反应信息

• 作为产物：
  描述：

  2-Amino-1-methylcarbamoyl-benzimidazol 以 1,4-二氧六环 为溶剂， 生成 (9CI)-n-1H-苯并咪唑-2-基-n-甲基-脲
  参考文献：
  名称：

  Graubaum, Heinz; Martin, Dieter; Szeibert, Dagmar, Journal fur praktische Chemie (Leipzig 1954), 1982, vol. 324, # 5, p. 809 - 815

  摘要：

  DOI：

文献信息

• MARTIN D.; GRAUBAUM H., J. PRAKT. CHEM., 1979, 321, NO 3, 379-386
  作者：MARTIN D.、 GRAUBAUM H.

  DOI：——

  日期：——
• HERPES VIRUS-BASED COMPOSITIONS AND METHODS OF USE IN THE PRENATAL AND PERINATAL PERIODS
  申请人：THE UNIVERSITY OF ROCHESTER

  公开号：EP1903873A2

  公开（公告）日：2008-04-02
• Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby
  申请人：West D. Michael

  公开号：US20080070303A1

  公开（公告）日：2008-03-20

  This invention generally relates to methods to differentiate pluripotent stem cells, such as embryonic stem, embryonic germ, or embryo-derived cells, to obtain subpopulations of cells from heterogeneous mixtures of cells wherein the subpopulation of cells possess reduced differentiation potential compared to the original pluripotent stem cells and where the subpopulation is capable of being propagated.
• Herpes Virus-Based Compositions and Methods of Use in the Prenatal and Perinatal Periods
  申请人：Federoff Howard J.

  公开号：US20080226601A1

  公开（公告）日：2008-09-18

  Disclosed are compositions and methods for reducing the severity of a birth defect in a mammal by exposing the mammal (e.g., in utero) to a herpes virus amplicon particle comprising a cis element-flanked transgene and a sequence encoding a transposase. Upon expression, the transposase inserts the transgene into the genome of a cell (e.g., a neuron) within the mammal and the transgene expresses a polypeptide or RNA that compensates for a protein or gene defect that is causally associated with the birth defect.
• METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY
  申请人：West Michael D.

  公开号：US20100184033A1

  公开（公告）日：2010-07-22

  Aspects of the present invention relate to methods to differentiate pluripotent primordial stem cells, such as human embryonic stem (“hES”) cells, human embryonic germ (“hEG”) cells, human embryo-derived (“hED”) cells and human embryonal carcinoma (“hEC”) cells, to obtain subpopulations of cells from heterogeneous mixtures of cells, wherein the subpopulation of cells possess reduced differentiation potential compared to the original pluripotent stem cells and where the subpopulation is capable of being propagated 20 or more population doublings. This invention also provides novel compositions of such subpopulations of cells and methods to propagate and differentiate said cells.