Ethyl hydroxyoctadecyl ether

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Ethyl hydroxyoctadecyl ether
• 英文别名: 18-ethoxyoctadecan-1-ol
• 化学式: C₂₀H₄₂O₂
• 分子量: 314.5
• InChiKey: LGWCRPOGKBCNDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  22
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] FUSED-RING COMPOUNDS, PHARMACEUTICAL COMPOSITION AND USES THEREOF<br/>[FR] COMPOSÉS À CYCLES CONDENSÉS, COMPOSITION PHARMACEUTIQUE ET UTILISATIONS ASSOCIÉES
  申请人：SHANGHAI DE NOVO PHARMATECH CO LTD

  公开号：WO2016131380A1

  公开（公告）日：2016-08-25

  This disclosure is related to a fused-ring compound of formula (I) and/or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the fused ring compound of formula (I) and/or a pharmaceutically acceptable salt thereof, preparation methods thereof, and use thereof in modulating activity of indoleamine 2, 3-dioxygenase (IDO) and/or tryptophan 2, 3-dioxygenase (TDO). This disclosure further provides methods of treating IDO and/or TDO-associated diseases, including cancer, viral infection and autoimmune diseases.

  这份披露涉及到式(I)的融合环化合物和/或其药学上可接受的盐，包括式(I)的融合环化合物和/或其药学上可接受的盐的药物组合物，其制备方法，以及在调节吲哚胺2,3-二氧化酶(IDO)和/或色氨酸2,3-二氧化酶(TDO)活性中的应用。这份披露还提供了治疗IDO和/或TDO相关疾病的方法，包括癌症、病毒感染和自身免疫疾病。
• [EN] SULFONYLAMINOCARBONYL DERIVATIVE, PHARMACEUTICAL COMPOSITION AND USES THEREOF<br/>[FR] DÉRIVÉ SULFONYLAMINOCARBONYLE, COMPOSITION PHARMACEUTIQUE ET UTILISATIONS ASSOCIÉES
  申请人：SHANGHAI DE NOVO PHARMATECH CO LTD

  公开号：WO2016173493A1

  公开（公告）日：2016-11-03

  This disclosure is related to a sulfonylaminocarbonyl derivative of formula (I) and/or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the sulfonylaminocarbonyl derivatives of formula (I) and/or a pharmaceutically acceptable salt thereof, preparation methods thereof, and use thereof in treating FXR and/or TGR5 mediated diseases, including primary biliary cirrhosis, nonalcoholic fatty liver, portal hypertension, bile acid diarrhea and cholestasis, type II diabetes and obesity, etc.

  本公开涉及一种式(I)的磺酰氨基甲酰衍生物和/或其药用可接受盐，包括该式(I)的磺酰氨基甲酰衍生物和/或其药用可接受盐的药物组合物，其制备方法以及在治疗FXR和/或TGR5介导的疾病中的应用，包括原发性胆汁性肝硬化、非酒精性脂肪肝、门静脉高压、胆酸性腹泻和胆汁淤积、2型糖尿病和肥胖症等。
• Skin irritation alleviation agent and composition thereof
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP0266921A2

  公开（公告）日：1988-05-11

  A skin irritation alleviation agent composed of a polyoxyalkylene-modified organopolysiloxane is provided. Various compositions including skin external application compositions, cosmetic or similar compositions (e.g., an adhesive composition for a false eyelash, a decolorant composition, a depilatory composition, and an eyeliner composition) containing a polyoxyalkylene-modified organosiloxane are also provided. This alleviation agent has a low skin irritation effect and extremely high safety factor when used on the human body.

  本发明提供了一种由聚氧亚烷基改性有机聚硅氧烷组成的皮肤过敏缓解剂。 还提供了含有聚氧亚烷基改性有机聚硅氧烷的各种组合物，包括皮肤外用组合物、化妆品或类似组合物（例如假睫毛粘合剂组合物、脱色剂组合物、脱毛剂组合物和眼线组合物）。 这种缓解剂用于人体时，皮肤刺激作用小，安全系数极高。
• Patch package structure
  申请人：NITTO DENKO CORPORATION

  公开号：EP1944001A1

  公开（公告）日：2008-07-16

  The present invention provides a patch package structure, which includes: a package including a first sheet material which is planar and a second sheet material which has been molded, the first and second sheet materials being sealed together in peripheral parts thereof, and a patch disposed in the package, in which the patch contains a backing, a pressure-sensitive adhesive layer laminated on at least one side of the backing, and a release liner which protects a pressure-sensitive adhesive surface of the pressure-sensitive adhesive layer; the second sheet material has been molded so as to have a protrudent part in at least a substantially central area thereof, the protrudent part having a planar outer shape larger than a planar outer shape of the release liner and having at least one recessed part; d is not smaller than T, in which d is the minimum gap distance between the inner surface of the first sheet material and the inner surface of the second sheet material at the recessed part and T is a thickness of the patch; and, at the boundary between the sealed part where the first and second sheet materials are sealed together and an unsealed part, the outer surface of the second sheet material rises at an obtuse angle.

  本发明提供了一种贴片封装结构，它包括一种包装，包括平面的第一片状材料和模制的第二片状材料，第一片状材料和第二片状材料在其周边部分密封在一起，以及一种贴片，贴片放置在包装中，其中贴片包含衬底、层压在衬底至少一面的压敏胶层和保护压敏胶层压敏胶表面的离型衬垫；第二种片状材料经过模压，至少在其大致中心区域具有一个突起部分，该突起部分的平面外部形状大于离型衬垫的平面外部形状，并具有至少一个凹陷部分；d 不小于 T，其中 d 是第一片状材料的内表面与第二片状材料的内表面在凹陷部分的最小间隙距离，T 是贴片的厚度；以及，在第一片状材料和第二片状材料密封在一起的密封部分与未密封部分之间的边界处，第二片状材料的外表面呈钝角上升。
• Patch and adhesive preperation
  申请人：Nitto Denko Corporation

  公开号：EP2025310A1

  公开（公告）日：2009-02-18

  The invention relates to a patch including a backing, a pressure-sensitive adhesive layer, and a release liner, the patch at an edge part thereof having such a sectional shape that, when a perpendicular segment is drawn from an edge of the backing at the edge part of the patch to the release liner, at least a part of an edge of the pressure-sensitive adhesive layer at the edge part of the patch is located on the center side of the patch with respect to the segment, and the edge of the pressure-sensitive adhesive layer being exposed. According to the invention, a patch and an adhesive preparation in each of which the pressure-sensitive adhesive is less apt to protrude or flow out from the edges thereof can be provided.

  本发明涉及一种贴片，包括背衬、压敏胶层和离型衬垫，贴片的边缘部分具有这样的断面形状：当从贴片边缘部分的背衬边缘到离型衬垫之间画出垂直线段时，贴片边缘部分的压敏胶层边缘的至少一部分位于贴片相对于该线段的中心侧，压敏胶层的边缘暴露在外。根据本发明，可以提供一种贴片和一种粘合剂制剂，其中每种贴片和制剂中的压敏胶都不易从其边缘突出或流出。