2-[[4-t-butylphenyl]amino]-N-(7-hydroxy-1-naphthyl)acetamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[[4-t-butylphenyl]amino]-N-(7-hydroxy-1-naphthyl)acetamide
• 英文别名: 2-(4-tert-butylanilino)-N-(7-hydroxynaphthalen-1-yl)acetamide
• 化学式: C₂₂H₂₄N₂O₂
• 分子量: 348.445
• InChiKey: YFRVJEGNITYAJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  61.4
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• [EN] NEW HYDROXYNAPHTHYL AMIDES<br/>[FR] HYDROXYNAPHTYLAMIDES
  申请人：ASTRAZENECA AB

  公开号：WO2004089877A1

  公开（公告）日：2004-10-21

  The present invention relates to new compounds of formula I, [Chemical formula should be inserted here. Please see paper copy] wherein R1, R2, R3, R4 and R5 are as defined as in formula I, or salts, solvates or solvated salts thereof, a process for their preparation, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy. The compounds are vanilloid receptor 1 (VR1) inhibitors and are useful in the treatment of a number of different disorders, for example acute and chronic neuropathic and inflammatory pain.

  本发明涉及公式I的新化合物，其中R1、R2、R3、R4和R5如公式I中所定义，或其盐、溶剂合物或溶剂化盐，以及它们的制备方法、含有所述化合物的药物组合物以及所述化合物在治疗中的应用。这些化合物是辣椒素受体1（VR1）抑制剂，对于治疗多种不同疾病，例如急性和慢性神经病理性和炎症性疼痛，具有用处。
• [EN] THERAPEUTIC RELEASE AGENTS<br/>[FR] AGENTS DE LIBÉRATION THÉRAPEUTIQUES
  申请人：ORGANON NV

  公开号：WO2008100977A2

  公开（公告）日：2008-08-21

  [EN] Pharmacological inhibition of fatty acid amide hydrolase (FAAH) activity leads to increased levels of fatty acid amides. Esters of alkylcarbamic acids are disclosed that are inhibitors of FAAH activity. Compounds disclosed herein inhibit FAAH activity. Described herein are processes for the preparation of esters of alkylcarbamic acid compounds, compositions that include them, and methods of use thereof.
  [FR] L'inhibition pharmacologique de l'activité de l'amide hydrolase d'acides gras (FAAH) entraîne une augmentation des taux d'amides d'acides gras. L'invention concerne des esters d'acides alkylcarbamiques qui constituent des inhibiteurs de l'activité de la FAAH. Les composés décrits inhibent l'activité de la FAAH. L'invention concerne aussi des procédés de préparation d'esters de composés d'acides alkylcarbamiques, des compositions renfermant ceux-ci et des procédés d'utilisation de celles-ci.