For-DL-Cys(1)-NHEtPh.For-DL-Cys(1)-NHEtPh

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: For-DL-Cys(1)-NHEtPh.For-DL-Cys(1)-NHEtPh
• 英文别名: 2-formamido-3-[[2-formamido-3-oxo-3-(2-phenylethylamino)propyl]disulfanyl]-N-(2-phenylethyl)propanamide
• 化学式: C₂₄H₃₀N₄O₄S₂
• 分子量: 502.7
• InChiKey: CJJFSGCWRHVWQH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  34
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  167
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• CYSTINE DERIVATIVES AS THERAPEUTIC AGENTS FOR MATRIX METALLOPROTEASE RELATED DISEASES
  申请人：Roche Diagnostics GmbH

  公开号：EP1143960A2

  公开（公告）日：2001-10-17
• [EN] CYSTINE DERIVATIVES AS THERAPEUTIC AGENTS FOR MATRIX METALLOPROTEASE RELATED DISEASES<br/>[FR] DERIVES DE CYSTINE EN TANT QU'AGENTS THERAPEUTIQUES POUR DES MALADIES LIEES AUX METALLOPROTEASES MATRICIELLES
  申请人：ROCHE DIAGNOSTICS GMBH

  公开号：WO2000027378A2

  公开（公告）日：2000-05-18

  Subject of the present invention are pharmaceutical compositions containing nonpeptidic cystine derivatives of general formula (I) wherein R1 and R3 may be the same or different and are selected from hydrogen, an aromatic or non-aromatic carbocyclic or heterocyclic ring or a linear or branched saturated or unsaturated alkyl group of 1 to 15 carbon atoms which can be interrupted by a hetero atom and which can be substituted by an aromatic or non-aromatic carbocyclic or heterocyclic ring. R2 and R4 may be the same or different and are selected from hydrogen, a linear or branched, saturated or unsaturated alkyl group of 1 to 15 carbon atoms which can be interrupted by a hetero atom and which can be substituted by an aromatic or non-aromatic carbocyclic or heterocyclic ring and A is a valency bond or a -CO-, -SO2-, -NHCO-, -NHCS- or -O-CO- group, their pharmacologically acceptable salts and optically active forms thereof and pharmaceutically acceptable carriers, for the treatment of diseases selected from tumor growth and metastasis, inflammatory diseases like osteo- and rheumatoid arthritis, osteoporosis, multiple sclerosis, periodontitis, restenosis, diseases caused by bacteria such as meningitis, sun-induced skin aging and Alzheimers disease and new compounds.