2-(1H-imidazol-5-yl)cyclopropane-1-carboxamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(1H-imidazol-5-yl)cyclopropane-1-carboxamide
• 化学式: C₇H₉N₃O
• 分子量: 151.17
• InChiKey: JAZKDQXFVBAXRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  71.8
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Novel alicyclic imidazoles as H3 agents
  申请人：——

  公开号：US20020042400A1

  公开（公告）日：2002-04-11

  Alicyclic imidazole compounds; pharmaceutically active compositions containing such compounds; and the use of such compounds in formulations for the control or prevention of disease states in which histamine H 3 receptors are involved, such as allergy, inflammation, hypotension, glaucoma, sleeping disorders, states of hyper- and hypo-motility of the gastro-intestinal tract, cardiovascular disease, hypo- and hyper-activity of the central nervous system, Alzheimer's, schizophrenia, obesity and migraines are disclosed.

  本文介绍了脂环咪唑化合物、含有这些化合物的药用组合物以及在控制或预防涉及组胺H3受体的疾病状态（如过敏、炎症、低血压、青光眼、睡眠障碍、胃肠道高低动力状态、心血管疾病、中枢神经系统低高活性、阿尔茨海默病、精神分裂症、肥胖症和偏头痛等）的制剂中使用此类化合物的方法。
• Novel alicylic imidazoles as H3 agents
  申请人：——

  公开号：US20040029943A1

  公开（公告）日：2004-02-12

  Alicyclic imidazole compounds; pharmaceutically active compositions containing such compounds; and the use of such compounds in formulations for the control or prevention of disease states in which histamine H 3 receptors are involved, such as allergy, inflammation, hypotension, glaucoma, sleeping disorders, states of hyper- and hypo-motility of the gastro-intestinal tract, cardiovascular disease, hypo- and hyper-activity of the central nervous system, Alzheimer's, schizophrenia, obesity and migraines are disclosed.

  本发明涉及脂环型咪唑化合物；含有这种化合物的药物活性组合物；以及在制剂中使用这种化合物来控制或预防组织胺H3受体参与的疾病状态，例如过敏、炎症、低血压、青光眼、睡眠障碍、胃肠道过度和过度活动状态、心血管疾病、中枢神经系统的低活性和高活性、阿尔茨海默病、精神分裂症、肥胖症和偏头痛。
• 2-(1H-4(5)-IMIDAZOYL) CYCLOPROPYL DERIVATIVES
  申请人：Gliatech, Inc.

  公开号：EP0837679B1

  公开（公告）日：2001-10-24
• US5990317A
  申请人：——

  公开号：US5990317A

  公开（公告）日：1999-11-23
• US6008240A
  申请人：——

  公开号：US6008240A

  公开（公告）日：1999-12-28