(E)-3-[4-(4-溴苯基)苯基]-3-(4-氯苯基)-N,N-二甲基丙-2-烯-1-胺 | 49857-37-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (E)-3-[4-(4-溴苯基)苯基]-3-(4-氯苯基)-N,N-二甲基丙-2-烯-1-胺
• 英文名称: [(E)-3-(4'-Bromo-biphenyl-4-yl)-3-(4-chloro-phenyl)-allyl]-dimethyl-amine
• 英文别名: Bbcda；(E)-3-[4-(4-bromophenyl)phenyl]-3-(4-chlorophenyl)-N,N-dimethylprop-2-en-1-amine
• CAS: 49857-37-6
• 化学式: C₂₃H₂₁BrClN
• 分子量: 426.783
• InChiKey: OISHCEIEGCYJDH-HZHRSRAPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-溴代联苯 、 alkaline earth salt of/the/ methylsulfuric acid 在 正丁基锂 、 三氯化铝 作用下， 以 二硫化碳 为溶剂， 反应 7.5h， 生成 (E)-3-[4-(4-溴苯基)苯基]-3-(4-氯苯基)-N,N-二甲基丙-2-烯-1-胺
  参考文献：
  名称：

  Synthesis and biological activities of N,N-dimethyl-2-propen-1-amine derivatives

  摘要：

  The synthesis of several 3-(4'-bromo[1,1'-biphenyl]-4-yl)-3-(4-X-phenyl)-N,N-dimethyl-2-propen-1-amine derivatives is described. These compounds are potential trypanocide agents with relative low acute toxicities. The inhibition of growth of Escherichia cell by these drugs with different para-substitution on the phenyl moiety and their trypanocidal activities against epimastigote from Trypanosoma cruzi were investigated.

  DOI：

  10.1016/s0223-5234(97)89856-x

文献信息

• Synthesis and biological activities of N,N-dimethyl-2-propen-1-amine derivatives
  作者：R De Conti、SMN Gimenez、M Haun、RA Pilli、SL De Castro、N Durán

  DOI：10.1016/s0223-5234(97)89856-x

  日期：1996.1

  The synthesis of several 3-(4'-bromo[1,1'-biphenyl]-4-yl)-3-(4-X-phenyl)-N,N-dimethyl-2-propen-1-amine derivatives is described. These compounds are potential trypanocide agents with relative low acute toxicities. The inhibition of growth of Escherichia cell by these drugs with different para-substitution on the phenyl moiety and their trypanocidal activities against epimastigote from Trypanosoma cruzi were investigated.