(2S)-2-amino-4-methylsulfanylbutanoic acid;(2S)-2-aminopropanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-amino-4-methylsulfanylbutanoic acid;(2S)-2-aminopropanoic acid
• 化学式: C8H18N2O4S
• 分子量: 238.31
• InChiKey: RRTKBMDIZBAHJK-ZBRNBAAYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.43
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  152
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• MODIFIED INTERLEUKIN-7 PROTEINS AND USES THEREOF
  申请人：GENEXINE, INC.

  公开号：US20210324027A1

  公开（公告）日：2021-10-21

  Provided are a modified IL-7 polypeptide and a fusion protein containing the modified IL-7 polypeptide. The fusion protein of the modified IL-7 includes: a first domain containing an interleukin-7 polypeptide; a second domain containing an oligopeptide having 1 to 10 amino acid residues (with proviso that the second domain excludes the oligopeptide consisting of methionine and/or glycine); and (c) a third domain which prolongs the half-life of the IL-7 fusion protein. The modified IL-7 polypeptide is composed of the (a) first domain and the (b) second domain. The modified IL-7 polypeptide and the fusion protein are expressed in a higher yield than the wild-type IL-7 and shows increased stability.

  提供的是经修改的IL-7多肽和含有经修改的IL-7多肽的融合蛋白。经修改的IL-7的融合蛋白包括：包含白细胞介素-7多肽的第一结构域；包含具有1至10个氨基酸残基的寡肽的第二结构域（但第二结构域不包括由蛋氨酸和/或甘氨酸组成的寡肽）；以及延长IL-7融合蛋白半衰期的第三结构域。经修改的IL-7多肽由第一结构域和第二结构域组成。经修改的IL-7多肽和融合蛋白的表达产量高于野生型IL-7，并显示出增加的稳定性。
• C-Terminal Attachment of Two Chemical Groups to Peptides
  申请人：Peschke Bernd

  公开号：US20100105617A1

  公开（公告）日：2010-04-29

  The present invention relates to a method for C-terminal attachment of two property-modifying groups to a peptide.

  本发明涉及一种将两个性质修饰基团附加到肽的C端的方法。
• Plants Tolerant to HPPD Inhibitor Herbicides
  申请人：Poree Fabien

  公开号：US20110191897A1

  公开（公告）日：2011-08-04

  The present invention relates to nucleic acid sequences encoding a hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, abbreviated herein as HPPD) obtained from protists belonging to the family Blepharismidae, as well as the proteins encoded thereby, and to a chimeric gene which comprises such nucleic acid sequence, and to the use of such nucleic acid sequences, proteins or chimeric genes for obtaining plants which are tolerant to HPPD inhibitor herbicides.

  本发明涉及编码来自睫毛虫科原生生物的羟基苯丙酮双氧酶（EC 1.13.11.27，以下简称HPPD）的核酸序列，以及由此编码的蛋白质，以及包括这样的核酸序列的嵌合基因，以及使用这样的核酸序列，蛋白质或嵌合基因来获得对HPPD抑制剂除草剂耐受的植物。
• Functional MRI agents for cancer imaging
  申请人：——

  公开号：US20040146463A1

  公开（公告）日：2004-07-29

  The invention relates to novel magnetic resonance imaging contrast agents for imaging cancer.

  本发明涉及用于癌症成像的新型磁共振成像对比剂。
• SULFUR ATOM-FREE ENZYME PROTEINS
  申请人：National Institute of Advanced Industrial Science and Technology

  公开号：EP1199355A1

  公开（公告）日：2002-04-24

  A sulfur atom-free enzyme protein retaining the activity of the original enzyme protein and having oxidation resistance wherein L-cystein and L-methionine residues of the enzyme protein are substituted with 18 types of L-amino acid residues: L-alanine; L-aspartic acid; L-glutamic acid; L-phenylalanine; L-glycine; L-histidine; L-isoleucine; L-lysine; L-leucine; L-asparagine; L-proline; L-glutamine; L-arginine; L-serine; L-threonine; L-valine; L-tyrosine; and L-tryptophan. A enzyme protein retaining the activity of the wild type enzyme while having antioxidation properties against oxidation by hydrogen peroxide, and the like and a process for producing the same.

  一种不含硫磺原子的酶蛋白，保留了原始酶蛋白的活性并具有抗氧化性，其中酶蛋白的L-半胱氨酸和L-蛋氨酸残基被18种L-氨基酸残基取代：L-丙氨酸、L-天冬氨酸、L-谷氨酸、L-苯丙氨酸、L-甘氨酸、L-组氨酸、L-异亮氨酸、L-赖氨酸、L-亮氨酸、L-天冬酰胺、L-脯氨酸、L-谷氨酰胺、L-精氨酸、L-丝氨酸、L-苏氨酸、L-缬氨酸、L-酪氨酸和 L-色氨酸。一种既能保持野生型酶的活性，又具有抗过氧化氢等氧化作用的酶蛋白及其生产工艺。