2-Hexyltetradecan-1-ol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-Hexyltetradecan-1-ol
• 化学式: C₂₀H₄₂O
• 分子量: 298.5
• InChiKey: PPIOFDABIWPIRW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.2
• 重原子数：
  21
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• TRANSDERMAL ABSORPTION PREPARATION
  申请人：Nitto Denko Corporation

  公开号：US20180311362A1

  公开（公告）日：2018-11-01

  Provided is a transdermal absorption preparation that shows superior skin permeability of a drug and that does not easily cause cold flow. A transdermal absorption preparation having a drug-containing layer containing a drug and a polymer, wherein 50-100 wt % of the polymer in the drug-containing layer is a polymer having a glass transition temperature of 30° C.-200° C., and the drug in the drug-containing layer is in an amorphous state.

  提供了一种经皮吸收制剂，该制剂具有卓越的药物皮肤渗透性，且不易引起冷流现象。该经皮吸收制剂包括一种药物含量层，其中包含药物和聚合物，其中药物含量层中的聚合物的50-100重量％为具有30℃-200℃玻璃转移温度的聚合物，而药物则处于非晶态。
• ADHESIVE SKIN PATCH
  申请人：Nitto Denko Corporation

  公开号：EP2540288A1

  公开（公告）日：2013-01-02

  The invention is intended to provide an adhesive patch which contains a drug except bisoprolol and which effectively inhibits the occurrence of oozing out or sticking out of the adhesive layer components from the exposed area of the adhesive layer of the adhesive patch during storage as well as the occurrence of oozing out of the drug from the adhesive layer thereby preventing the reduction in drug content. The support, the release liner and the adhesive layer constituting the adhesive patch each are formed to have a rectangular planar shape and the entire adhesive patch are formed to have a rectangular planar shape, and a protrudent part is formed on the support-side surface of the adhesive patch at a corner thereof. In addition, the adhesive patch may be formed to have a middle part and a peripheral part, and the protrudent part may be formed at a corner of the rectangular middle part. Further, between the adjacent at least two protrudent parts, a connecting built-up part may be provided in which the thickness of the adhesive patch is smaller than the thickness of the adhesive patch in the protrudent part. In case where the release liner has a split part, the split part is made so as not to traverse the protrudent part.

  本发明的目的是提供一种含有除比索洛尔以外的药物的粘合贴片，该粘合贴片可有效抑制粘合层成分在储存期间从粘合贴片的粘合层暴露区域渗出或粘出的情况以及药物从粘合层渗出的情况，从而防止药物含量减少。构成粘贴片的支架、离型衬垫和粘合剂层各自形成为矩形平面形状，整个粘贴片形成为矩形平面形状，并且在粘贴片的支架侧表面的一角处形成突起部分。此外，粘贴片还可以形成中间部分和外围部分，突起部分可以形成在矩形中间部分的一个角上。此外，在相邻的至少两个突起部分之间，可以设置一个连接内置部分，其中粘合剂贴片的厚度小于突起部分中粘合剂贴片的厚度。如果离型纸衬垫有分割部分，则分割部分不得穿过突起部分。
• ADHESIVE PATCH CONTAINING BISOPROLOL
  申请人：Nitto Denko Corporation

  公开号：EP2540289A1

  公开（公告）日：2013-01-02

  The invention is intended to provide an adhesive patch which effectively inhibits the occurrence of oozing out or sticking out of the adhesive layer components from the exposed area of the adhesive layer of the adhesive patch during storage as well as the occurrence of oozing of bisoprolol or a salt thereof from the adhesive layer thereby preventing the reduction in drug content. The support, the release liner and the adhesive layer constituting the adhesive patch each are formed to have a rectangular planar shape and the entire adhesive patch are formed to have a rectangular planar shape, and a protrudent part is formed on the support-side surface of the adhesive patch at a corner thereof. In addition, the adhesive patch may be formed to have a middle part and a peripheral part, and the protrudent part may be formed at a corner of the rectangular middle part. Further, between the adjacent at least two protrudent parts, a connecting built-up part may be provided in which the thickness of the adhesive patch is smaller than the thickness of the adhesive patch in the protrudent part. In case where the release liner has a split part, the split part is made so as not to traverse the protrudent part.

  本发明旨在提供一种粘贴剂，它能有效地抑制粘贴剂在储存期间从粘贴剂的粘合层暴露区域渗出或粘出粘合层成分，以及从粘合层渗出比索洛尔或其盐，从而防止药物含量减少。构成粘贴片的支架、离型衬垫和粘合剂层各自形成为矩形平面形状，整个粘贴片形成为矩形平面形状，并且在粘贴片的支架侧表面的一角处形成突起部分。此外，粘贴片还可以形成中间部分和外围部分，突起部分可以形成在矩形中间部分的一个角上。此外，在相邻的至少两个突起部分之间，可以设置一个连接内置部分，其中粘合剂贴片的厚度小于突起部分中粘合剂贴片的厚度。如果离型纸衬垫有分割部分，则分割部分不得穿过突起部分。
• PACKAGING STRUCTURE FOR PATCHES
  申请人：Nitto Denko Corporation

  公开号：EP2733087A2

  公开（公告）日：2014-05-21

  A purpose of the present invention is to provide a packaging structure for a patch, in which the patch can be easily taken out of a package body. The packaging structure (100) for a patch includes a first and second base materials (120, 130) which have a peripheral edge part laminated with each other, and the patch is included therein. The first and second base materials (120, 130) have a first to forth sides (121 to 124, 131 to 134). At least one of the first and second base materials (120, 130) has a first to third opening parts (125 to 127, 135 to 137). The first to third opening parts (125 to 127, 135 to 137) guides so as to open toward the inner peripheral edge (120c1, 120c2, 120c4, 130c1, 130c2, 130c4) of the sealing part (120c, 130c).

  本发明的目的是提供一种用于贴片的包装结构，其中的贴片可以很容易地从包装体中取出。用于贴片的包装结构（100）包括第一和第二基材（120、130），它们的外围边缘部分相互层压，贴片包含在其中。第一和第二基材（120、130）具有第一至第四侧（121 至 124、131 至 134）。第一和第二基底材料（120、130）中至少有一个具有第一至第三开口部分（125 至 127、135 至 137）。第一至第三开口部件（125 至 127、135 至 137）导向密封部件（120c、130c）的内周边缘（120c1、120c2、120c4、130c1、130c2、130c4）。
• TRANSDERMAL ABSORPTION PREPARATION PRECURSOR
  申请人：Nitto Denko Corporation

  公开号：EP3395337A1

  公开（公告）日：2018-10-31

  A transdermal absorption preparation precursor 50 containing a release liner 10 containing one first valley fold part 1, one or two first mountain fold parts 2, and a first base line L1 and a second base line L2 on one side and the other side apart from the first valley fold part 1 as a line of demarcation and at an approximately equal distance from the first valley fold part 1, wherein at least one of the first base line L1 and the second base line L2 is a fold line of the first mountain fold part 2, and a drug-containing layer 3 having a center line laid on the first base line L1 and an adhesive layer 4 having a center line laid on the second base line L2 on the release liner 10.

  一种透皮吸收制剂前体 50，包含一个释放衬垫 10，该释放衬垫 10 包含一个第一山谷褶皱部分 1、一个或两个第一山峰褶皱部分 2，以及第一基线 L1 和第二基线 L2，它们分别位于与第一山谷褶皱部分 1 相隔的一侧和另一侧，作为第一山谷褶皱部分 1 的分界线，且与第一山谷褶皱部分 1 的距离大致相等、其中，第一基线 L1 和第二基线 L2 中至少有一条是第一山形折叠部分 2 的折叠线，在离型纸衬垫 10 上铺设有中心线位于第一基线 L1 上的含药层 3 和中心线位于第二基线 L2 上的粘合剂层 4。