3-(4-Methyl-piperidine-1-sulfonyl)-5-phenyl-pentanoic acid | 260046-71-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-(4-Methyl-piperidine-1-sulfonyl)-5-phenyl-pentanoic acid
• 英文别名: 3-(4-Methylpiperidin-1-yl)sulfonyl-5-phenylpentanoic acid
• CAS: 260046-71-7
• 化学式: C₁₇H₂₅NO₄S
• 分子量: 339.456
• InChiKey: FHIJRNJVHZVCOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  83.1
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Hydroxamic acid derivatives as proteinase inhibitors
  申请人：British Biotech Pharmaceuticals Ltd.

  公开号：US20030050310A1

  公开（公告）日：2003-03-13

  Compounds of formula (I) are matrix metalloproteinase inhibitors wherein X represents a carboxylic acid group —COOH, or a hydroxamic acid group —CONHOH;R 2 represents a radical of formula (II): R 3 —(ALK) m —(Q) p —(ALK) n —, and W represents a cyclic amino radical of formula (IIIA) or (IIIB): 1

  公式（I）的化合物是基质金属蛋白酶抑制剂，其中X表示羧酸基- COOH或羟肟酸基- CONHOH；R2表示公式（II）的基团：R3-（ALK）m-（Q）p-（ALK）n-，W表示公式（IIIA）或（IIIB）的环状氨基基团：1。
• HYDROXAMIC ACID DERIVATIVES AS PROTEINASE INHIBITORS
  申请人：BRITISH BIOTECH PHARMACEUTICALS LIMITED

  公开号：EP1107953A1

  公开（公告）日：2001-06-20
• US6479502B1
  申请人：——

  公开号：US6479502B1

  公开（公告）日：2002-11-12
• [EN] HYDROXAMIC ACID DERIVATIVES AS PROTEINASE INHIBITORS<br/>[FR] DERIVES D'ACIDE HYDROXAMIQUE COMME INHIBITEURS DE PROTEINASE
  申请人：BRITISH BIOTECH PHARM

  公开号：WO2000012477A1

  公开（公告）日：2000-03-09

  Compounds of formula (I) are matrix metalloproteinase inhibitors wherein X represents a carboxylic acid group -COOH, or a hydroxamic acid group -CONHOH; R2 represents a radical of the formula (II): R3-(ALK)m-(Q)p-(ALK)n-, and W represents a cyclic amino radical of formula (IIIA) or (IIIB).