2-[4-(3-chlorobenzyloxy)benzylamino]propanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[4-(3-chlorobenzyloxy)benzylamino]propanamide
• 英文别名: 2-[4-(3-chlorobenzyloxy)benzyl]aminopropionamide；2-[[4-[(3-Chlorophenyl)methoxy]phenyl]methylamino]propanamide
• 化学式: C₁₇H₁₉ClN₂O₂
• 分子量: 318.803
• InChiKey: JFADNUHMEURSIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Alpha-aminoamide derivatives useful in the treatment of lower urinary tract disorders
  申请人：Newron Pharmaceuticals S.p.A.

  公开号：EP1557166A1

  公开（公告）日：2005-07-27

  Methods of using certain α-aminoamide derivatives to treat lower urinary tract disorders. The therapeutic agents of the invention are able to reduce or even stop the lower urinary tract disorders substantially without side effects.

  使用某些α-氨基酰胺衍生物的方法来治疗下尿路障碍。该发明的治疗剂能够在没有副作用的情况下显著减少甚至停止下尿路障碍。
• ALPHA-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSYCHIATRIC DISORDERS
  申请人：Izzo Emanuela

  公开号：US20110014304A1

  公开（公告）日：2011-01-20

  The disclosure relates to pharmacotherapy of a psychiatric disorder which is schizophrenia and/or anxiety, wherein schizophrenia includes schizophrenia related disorders such as brief psychotic disorders, delusional disorders, schizoaffective disorders, and schizophreniform disorders, and anxiety includes panic disorders, obsessive-compulsive disorders (OCD), post-traumatic stress disorders (PTSD), social phobia or social anxiety disorders, specific phobia, and generalized anxiety disorders (GAD). The compounds of the disclosure are useful for the treatment of the above psychiatric disorders alone or in combination with other therapeutical agents effective in the treatment of schizophrenia and/or anxiety disorders.

  本公开涉及药物治疗精神障碍，其中包括精神分裂症和/或焦虑症，其中精神分裂症包括与之相关的疾病，如短暂性精神病性障碍、妄想性障碍、情感性精神病性障碍和分裂症样障碍，而焦虑症包括惊恐障碍、强迫症、创伤后应激障碍、社交恐惧症或社交焦虑症、特定恐惧症和广泛性焦虑症。本公开的化合物可用于治疗上述精神障碍，单独使用或与其他治疗精神分裂症和/或焦虑症有效的治疗剂联合使用。
• [EN] N-PHENYLALKYL SUBSTITUTED (ALPHA)-AMINO CARBOXAMIDE DERIVATIVES AND PROCESS FOR THEIR PREPARATION
  申请人：FARMITALIA CARLO ERBA S.R.L.

  公开号：WO1990014334A1

  公开（公告）日：1990-11-29

  (EN) N-phenylalkyl substituted $g(a)-amino carboxamide derivatives of formula (I), wherein R is C1-C8 alkyl, C3-C8 cycloalkyl, furyl, thienyl, pyridyl or unsubstituted or substituted phenyl; A is a -(CH2)m- or -(CH2)p-X-(CH2)q- group wherein X is -O-, -S- or -NR4-; R1, R2, R3, R'3, R4, n, m, p and q are as herein defined; and each of R5 and R6 is independently hydrogen or C1-C6 alkyl, and the pharmaceutically acceptable salts thereof, are active on the central nervous system and can be used as anti-epileptic, anti-Parkinson, neuroprotective, antidepressant, antispastic and/or hypnotic agents in mammals.(FR) Ces dérivés correspondent à la formule (I), où R est alkyle C1-C8, cycloalkyle C3-C8, furyle, thiényle, pyridyle ou phényle, substitué ou non; A est un groupe -(CH2)m- ou -(CH2)p-X-(CH2)q-, où X est -O-, -S- ou NR4-; R1, R2, R3, R'3, R4, n, m, p et q ont les significations indiquées dans la description; et R5 et R6 sont chacun, indépendamment l'un de l'autre, hydrogène ou alkyle C1-C6. L'invention porte également sur leurs sels pharmaceutiquement acceptables. Ces dérivés et leurs sels agissent sur le système nerveux central et peuvent servir d'agents anti-épileptiques, anti-Parkinson, neuroprotecteurs, antidépressifs, antispastiques et/ou hypnotiques chez les mammifères.

  N-苯基烷基取代的$g(a)-氨基羧酰胺衍生物的化学式(I)，其中R为C1-C8烷基，C3-C8环烷基，呋喃基，噻吩基，吡啶基或未取代或取代的苯基；A为-(CH2)m-或-(CH2)p-X-(CH2)q-基团，其中X为-O-，-S-或-NR4-；R1，R2，R3，R'3，R4，n，m，p和q如本文所定义；R5和R6各自独立为氢或C1-C6烷基，以及其药学上可接受的盐，在哺乳动物的中枢神经系统中具有活性，可用作抗癫痫、抗帕金森、神经保护、抗抑郁、抗痉挛和/或催眠剂。
• (Halobenzyloxy) Benzylamino-Propanamides as Sodium and/or Calcium Channel Selective Modulators
  申请人：Barbanti Elena

  公开号：US20080096965A1

  公开（公告）日：2008-04-24

  The invention relates to the use of selected (R)-2-[(halobenzyloxy)benzylamino]-propanamides and the pharmaceutically acceptable salts thereof for the manufacture of medicament, that are selectively active assodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, pain, migraine, periferal diseases, cardiovascular diseases, inflammatory processes affecting all body systems, disorders affecting skin and related tissues, disorders of the respiratory system, disorders of the immune and endocrinological systems, gastrointestinal, urogenital, metabolic and seizure disorders, where the above mechanisms have been described as playing a pathological role.

  本发明涉及选定的（R）-2-[(卤代苯氧基)苯基氨基]-丙酰胺及其药学上可接受的盐的使用，用于制备药物，这些药物是选择性作用于钠和/或钙通道调节剂，因此有助于预防、缓解和治疗各种病理状况，包括疼痛、偏头痛、周围疾病、心血管疾病、影响全身系统的炎症过程、影响皮肤和相关组织的疾病、呼吸系统疾病、免疫和内分泌系统疾病、胃肠道、泌尿生殖系统、代谢和癫痫疾病，上述机制已被描述为发挥病理作用。
• Alpha-Aminoamide Derivatives Useful in the Treatment of Lower Urinary Tract Disorders
  申请人：Barbanti Elena

  公开号：US20080132567A1

  公开（公告）日：2008-06-05

  Methods of using certain α-aminoamide derivatives to treat lower urinary tract disorders. The therapeutic agents of the invention are able to reduce or even stop the lower urinary tract disorders substantially without side effects.

  使用某些α-氨基酰胺衍生物来治疗下尿路障碍的方法。本发明的治疗剂能够在几乎没有副作用的情况下显著减轻甚至停止下尿路障碍。