3-[[3-(2-Piperidin-4-ylethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine-8-carbonyl]amino]propanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-[[3-(2-Piperidin-4-ylethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine-8-carbonyl]amino]propanoic acid
• 化学式: C₁₇H₂₇N₅O₃
• 分子量: 349.4
• InChiKey: AEPQNGNJINUOMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.7
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  109
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• TRIAZOLOPYRIDINES FOR THE TREATMENT OF THROMBOSIS DISORDERS
  申请人：Ortho-McNeil Pharmaceutical, Inc.

  公开号：EP1102766A1

  公开（公告）日：2001-05-30
• US6303625B1
  申请人：——

  公开号：US6303625B1

  公开（公告）日：2001-10-16
• [EN] TRIAZOLOPYRIDINES FOR THE TREATMENT OF THROMBOSIS DISORDERS<br/>[FR] TRIAZOLOPYRIDINES POUR TRAITER LES DYSFONCTIONNEMENTS THROMBOTIQUES
  申请人：ORTHO MCNEIL PHARM INC

  公开号：WO2000006570A1

  公开（公告）日：2000-02-10

  The invention is directed to novel triazolopyridine derivatives which are useful as antagonists of GPIIb/IIIa. Pharmaceutical compositions comprising the triazolopyridine derivatives of the present invention, methods of treating conditions mediated by GPIIb/IIIa (e.g., methods for treating platelet-mediated thrombotic disorders) along with processes for making the compounds and novel intermediates are also disclosed.