2-(4-{3-[2-(phenylmethoxy)phenyl]-2-thienyl}phenyl) acetic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(4-{3-[2-(phenylmethoxy)phenyl]-2-thienyl}phenyl) acetic acid
• 英文别名: 2-[4-[3-(2-Phenylmethoxyphenyl)thiophen-2-yl]phenyl]acetic acid
• 化学式: C₂₅H₂₀O₃S
• 分子量: 400.498
• InChiKey: IKHIDJYLNLHRLH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  74.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Method of treating or preventing urinary incontinence using prostanoid EP1 receptor antagonists
  申请人：——

  公开号：US20020137746A1

  公开（公告）日：2002-09-26

  This invention encompasses a method of treating or preventing urinary incontinence in a mammalian patient comprising administering to the patient a compound of formula I: 1 or a pharmaceutically acceptable salt, hydrate or ester thereof. The invention also encompasses certain pharmaceutical compositions and methods for treatment of prostaglandin mediated diseases comprising the use of compounds of formula I.

  这项发明涵盖了一种治疗或预防哺乳动物患者尿失禁的方法，包括向患者施用式I的化合物：1或其药学上可接受的盐、水合物或酯。该发明还涵盖了某些药物组合物和治疗前列腺素介导疾病的方法，包括使用式I的化合物。
• CARBOXYLIC ACIDS AND ACYLSULFONAMIDES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
  申请人：MERCK FROSST CANADA & CO.

  公开号：EP1216238B1

  公开（公告）日：2004-02-18
• US6369084B1
  申请人：——

  公开号：US6369084B1

  公开（公告）日：2002-04-09
• [EN] CARBOXYLIC ACIDS AND ACYLSULFONAMIDES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT<br/>[FR] ACIDES CARBOXYLIQUES ET ACYLSULFONAMIDES, COMPOSITIONS CONTENANT DE TELS COMPOSES ET METHODES DE TRAITEMENT
  申请人：MERCK FROSST CANADA INC

  公开号：WO2001019814A2

  公开（公告）日：2001-03-22

  This invention encompasses the novel compounds of formula (A), which are useful in the treatment of prostaglandin mediated diseases, or a pharmaceutically acceptable salt, hydrate or ester thereof. The invention also encompasses certain pharmaceutical compositions and methods for treatment of prostaglandin mediated diseases comprising the use of compounds of formula (A).