2-[2-[[3-(1,3-benzodioxol-5-yloxy)-2-hydroxypropyl]-methylamino]ethyl-methylamino]-N-(2,6-dimethylphenyl)acetamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[2-[[3-(1,3-benzodioxol-5-yloxy)-2-hydroxypropyl]-methylamino]ethyl-methylamino]-N-(2,6-dimethylphenyl)acetamide
• 化学式: C₂₄H₃₃N₃O₅
• 分子量: 443.5
• InChiKey: GQVANRJFVQCQDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  32
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  83.5
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Substituted alkylene diamine compounds
  申请人：——

  公开号：US20010036961A1

  公开（公告）日：2001-11-01

  Novel compounds of the general formula: 1 and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage resulting from trauma or to protect skeletal muscles subsequent to muscle or systemic diseases such as intermittent claudication, to treat shock conditions, to preserve donor tissue and organs used in transplants, in the treatment of cardiovascular diseases including atrial and ventricular arrhythmias, Prinzmetal's (variant) angina, stable angina, and exercise induced angina, congestive heart disease, and myocardial infarction.

  该通用公式的新化合物：1及其药学上可接受的酸盐加成物，其中这些化合物可用于治疗，以保护骨骼肌免受创伤造成的损伤，或在肌肉或系统疾病（如间歇性跛行症）后保护骨骼肌，治疗休克状态，保护用于移植的供体组织和器官，在治疗心血管疾病包括心房和心室心律失常、普林兹梅塔尔（变异型）心绞痛、稳定型心绞痛和运动诱发型心绞痛、充血性心力衰竭和心肌梗死方面使用。
• US6638970B2
  申请人：——

  公开号：US6638970B2

  公开（公告）日：2003-10-28
• [EN] SUBSTITUTED ALKYLENE DIAMINE COMPOUNDS<br/>[FR] COMPOSES ALKYLENE DIAMINE SUBSTITUES
  申请人：CV THERAPEUTICS INC

  公开号：WO2001062711A2

  公开（公告）日：2001-08-30

  Novel compounds of the general formula (I) and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage resulting from trauma or to protect skeletal muscles subsequent to muscle or systemic diseases such as intermittent claudication, to treat shock conditions, to preserve donor tissue and organs used in transplants, in the treatment of cardiovascular diseases including atrial and ventricular arrhythmias, Prinzmetal's (variant) angina, stable angina, and exercise induced angina, congestive heart disease, and myocardial infarction.