Z-L-Abu-CONH(CH2)3-morpholine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Z-L-Abu-CONH(CH2)3-morpholine
• 英文别名: benzyl N-[4-methyl-1-[[1-(3-morpholin-4-ylpropylamino)-1,2-dioxopentan-3-yl]amino]-1-oxopentan-2-yl]carbamate
• 化学式: C₂₆H₄₀N₄O₆
• 分子量: 504.6
• InChiKey: TZVQRMYLYQNBOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  36
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  126
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Polynucleotide encoding a novel cysteine protease of the calpain superfamily, CAN-12, and variants thereof
  申请人：——

  公开号：US20030114373A1

  公开（公告）日：2003-06-19

  The present invention provides novel polynucleotides encoding CAN-12 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants of CAN-12 polypeptides, CAN-12v1 and CAN-12v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel CAN-12, CAN-12v1, and CAN-12v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly neuro- and musculo-degenerative conditions. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

  本发明提供了编码 CAN-12 多肽、其片段和同源物的新型多核苷酸。本发明还提供了编码 CAN-12 多肽变体 CAN-12v1 和 CAN-12v2 的多核苷酸。本发明还提供了生产上述多肽的载体、宿主细胞、抗体以及重组和合成方法。本发明进一步涉及将这些新型 CAN-12、CAN-12v1 和 CAN-12v2 多肽应用于诊断、治疗和/或预防与这些多肽相关的各种疾病和/或失调的诊断和治疗方法，特别是神经和肌肉退行性疾病。本发明进一步涉及鉴定本发明多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
• EP1567642A4
  申请人：——

  公开号：EP1567642A4

  公开（公告）日：2006-02-08
• POLYNUCLEOTIDE ENCODING A NOVEL CYSTEINE PROTEASE OF THE CALPAIN SUPERFAMILY, CAN-12, AND VARIANTS THEREOF
  申请人：Bristol-Myers Squibb Company

  公开号：EP1567642A2

  公开（公告）日：2005-08-31
• POLYNUCLEOTIDE ENCODING A NOVEL CYSTEINE PROTEASE OF THE CALPAIN SUPERFAMILY, PROTEASE-42
  申请人：Bristol-Myers Squibb Company

  公开号：EP1572926A2

  公开（公告）日：2005-09-14
• Polynucleotide encoding a novel cysteine protease of the calpain superfamily, Protease-42
  申请人：——

  公开号：US20040014093A1

  公开（公告）日：2004-01-22

  The present invention provides novel polynucleotides encoding Protease-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel Protease-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.