(R)-(+)-1-(2-甲氧基苯甲酰基)-2-吡咯烷甲醇 | 207511-15-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (R)-(+)-1-(2-甲氧基苯甲酰基)-2-吡咯烷甲醇
• 中文别名: (R)-(+)-1-(2-甲氧基苯甲酰)-2-吡咯烷甲醇
• 英文名称: (R)-1-(2-methoxybenzoyl)-2-pyrrolidinemethanol
• 英文别名: (R)-(+)-1-(2-Methoxybenzoyl)-2-pyrrolidinemethanol；[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]-(2-methoxyphenyl)methanone
• CAS: 207511-15-7
• 化学式: C₁₃H₁₇NO₃
• mdl: MFCD00075326
• 分子量: 235.283
• InChiKey: ZPRSXRGRMZPZQY-SNVBAGLBSA-N

物化性质

• 熔点：
  104-106 °C (lit.)
• 稳定性/保质期：
  避免与水分和强氧化剂接触。

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.461
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险品标志：
  Xi
• WGK Germany：
  3

反应信息

• 作为反应物：
  描述：

  (R)-(+)-1-(2-甲氧基苯甲酰基)-2-吡咯烷甲醇 、 三氟乙酸酐 生成 Trifluoro-acetic acid (R)-1-(2-methoxy-benzoyl)-pyrrolidin-2-ylmethyl ester
  参考文献：
  名称：

  Enantiomeric impurities in chiral synthons, catalysts, and auxiliaries: Part 3

  摘要：

  The enantiomeric excess of chiral reagents used in asymmetric syntheses directly affects the reaction selectivity and product purity. In this work, 84 of the more recently available chiral compounds were evaluated to determine their actual enantiomeric composition. These compounds are widely used in asymmetric syntheses as chiral synthons, catalysts, and auxiliaries. These include chiral alcohols, amines, amino alcohols, amides, carboxylic acids, epoxides, esters, ketones, and oxolanes among other classes of compounds. All enantiomeric test results were categorized within five impurity levels (i.e., < 0.01%, 0.01-0.1%, 0.1-1%, 1-10%, and > 10%). The majority of the reagents tested were determined to have enantiomeric impurities over 0.01%, and two of them were found to contain enantiomeric impurities exceeding the 10% level. The most effective enantio selective analysis method was a GC approach using a Chiraldex GTA chiral stationary phase (CSP). This method worked exceedingly well with chiral amines and alcohols. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.10.014

文献信息

• [EN] 3-(5-METHOXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS DE 3-(5-MÉTHOXY-1-OXOISOINDOLIN-2-YL)PIPÉRIDINE-2,6-DIONE ET LEURS UTILISATIONS
  申请人：NOVARTIS AG

  公开号：WO2021124172A1

  公开（公告）日：2021-06-24

  The present disclosure relates to compounds of formula (I') and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

  本公开涉及式(I')的化合物、药物组合物及其在降低广泛间隔锌指蛋白结构域（WIZ）表达水平、诱导胎儿血红蛋白（HbF）表达以及治疗遗传性血液疾病（例如，血红蛋白病，例如，β-血红蛋白病）方面的用途，如镰状细胞病和β-地中海贫血。
• Antagonists of melanin concentrating hormone effects on the melanin concetrating hormone receptor
  申请人：——

  公开号：US20030229119A1

  公开（公告）日：2003-12-11

  The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.

  本发明涉及通过黑素浓缩激素受体对黑素浓缩激素（MCH）效果的拮抗，对于预防或治疗进食障碍、体重增加、肥胖、生殖和性行为异常、甲状腺激素分泌、利尿和水/电解质平衡、感觉处理、记忆、睡眠、觉醒、焦虑、抑郁、癫痫发作、神经退行性疾病和精神疾病是有用的。
• 3-(5-methoxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione Derivatives and Uses thereof
  申请人：NOVARTIS AG

  公开号：US20220402904A1

  公开（公告）日：2022-12-22

  The present disclosure relates to compounds of formula (I′) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.
• US6818772B2
  申请人：——

  公开号：US6818772B2

  公开（公告）日：2004-11-16
• [EN] ANTAGONIST OF MELANIN CONCENTRATING HORMONE AND THEIR USES<br/>[FR] ANTAGONISTE DES EFFETS D'UNE HORMONE DE CONCENTRATION DE MELANINE ET SON UTILISATION
  申请人：ABBOTT LAB

  公开号：WO2003070244A1

  公开（公告）日：2003-08-28

  The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders. The present invention is directed to the compouds of formula (I).