(2S)-2-[(2-chlorobenzoyl)amino]-3-[4-[3-(cyanomethyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl]oxyphenyl]propanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-[(2-chlorobenzoyl)amino]-3-[4-[3-(cyanomethyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl]oxyphenyl]propanoic acid
• 化学式: C₃₀H₂₈ClN₃O₇
• 分子量: 578.0
• InChiKey: PUHIOEXSABPBEO-QBGQUKIHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  41
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  138
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Method for Augmenting B Cell Depletion
  申请人：Chan C. Andrew

  公开号：US20080075719A1

  公开（公告）日：2008-03-27

  The present invention provides methods of augmenting B cell depletion by promoting intravascular access of B cell subsets sequestered in lymphoid tissues rendering the B cells sensitive to killing mediated by the B cell depleting agent. One method of promoting intravascular access is by the use of integrin antagonists. Methods of treating B cell disorders by this approach is also provided.
• US7595399B2
  申请人：——

  公开号：US7595399B2

  公开（公告）日：2009-09-29
• [EN] METHOD FOR AUGMENTING B CELL DEPLETION<br/>[FR] METHODE PERMETTANT D'AUGMENTER L'APPAUVRISSEMENT DES LYMPHOCYTES B
  申请人：GENENTECH INC

  公开号：WO2005113003A2

  公开（公告）日：2005-12-01

  The present invention provides methods of augmenting B cell depletion by promoting intravascular access of B cell subsets sequestered in lymphoid tissues rendering the B cells sensitive to killing mediated by the B cell depleting agent. One method of promoting intravascular access is by the use of integrin antagonists. Methods of treating B cell disorders by this approach is also provided.