(S)-2-(2-Benzoyl-phenylamino)-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]propionic acid | 494221-10-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-(2-Benzoyl-phenylamino)-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]propionic acid
• 英文别名: (S)-2-(2-Benzoyl-phenylamino)-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]-propionic Acid；(2S)-2-(2-benzoylanilino)-3-[4-(2-phenoxazin-10-ylethoxy)phenyl]propanoic acid
• CAS: 494221-10-2
• 化学式: C₃₆H₃₀N₂O₅
• 分子量: 570.645
• InChiKey: ZRVJZXORIYEJHJ-PMERELPUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.3
• 重原子数：
  43
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  88.1
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  (S)-2-(2-Benzoyl-phenylamino)-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]propionic acid methyl ester 在 sodium hydroxide 作用下， 以 乙醇 、 二氯甲烷 、 水 为溶剂， 以210 mg (94%)的产率得到(S)-2-(2-Benzoyl-phenylamino)-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]propionic acid
  参考文献：
  名称：

  US2003/55076

  摘要：

  公开号：

文献信息

• Novel compounds, their preparation and use
  申请人：——

  公开号：US20030055076A1

  公开（公告）日：2003-03-20

  Novel compounds of the general formula (I), the use of these compounds as medicaments, pharmaceuticaly compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR). The compounds exert their effects by modulating the PPAR&ggr; response in a partial agonist manner.

  本发明涉及一般式（I）的新化合物，这些化合物作为药物的用途，包括这些化合物的制药组合物和使用这些化合物和组合物的治疗方法。这些化合物可能在治疗和/或预防由核受体介导的疾病方面有用，特别是过氧化物酶体增殖物激活受体（PPAR）。这些化合物通过以部分激动剂方式调节PPAR&ggr;反应来发挥作用。
• NOVEL VINYL N-(2-BENZOYLPHENYL)-L-TYROSINE DERIVATIVES AND THEIR USE AS ANTIDIABETICS ETC
  申请人：NOVO NORDISK A/S

  公开号：EP1414806A1

  公开（公告）日：2004-05-06
• SYSTEMS AND METHODS FOR ENHANCING VACCINE EFFICACY
  申请人：Phipps Richard P.

  公开号：US20110300129A1

  公开（公告）日：2011-12-08

  Pharmaceutical compositions of the invention include an antigen or a nucleic acid molecule encoding the antigen; one or both of a PPAR ligand and an RxR ligand; and a pharmaceutically suitable carrier. The pharmaceutical composition can optionally include a mitogen or other additives. Also disclosed are methods of inducing B cell differentiation and promoting an immune response against an antigen.
• [EN] NOVEL VINYL N-(2-BENZOYLPHENYL)-L-TYROSINE DERIVATIVES AND THEIR USE AS ANTIDIABETICS ETC<br/>[FR] NOUVEAUX DERIVES DE VINYL N-(2-BENZOYLPHENYL)-L-TYROSINE ET LEUR UTILISATION EN TANT QU'ANTIDIABETIQUES ETC.
  申请人：NOVO NORDISK AS

  公开号：WO2003011834A1

  公开（公告）日：2003-02-13

  Novel compounds of the general formula (I), the use of these compounds as medicaments, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR). The compounds exert their effects by modulating the PPARη response in a partial agonist manner.
• [EN] SYSTEMS AND METHODS FOR ENHANCING VACCINE EFFICACY<br/>[FR] SYSTÈMES ET PROCÉDÉS POUR AMÉLIORER L'EFFICACITÉ DE VACCINS
  申请人：UNIV ROCHESTER

  公开号：WO2010075037A1

  公开（公告）日：2010-07-01

  Pharmaceutical compositions of the invention include an antigen or a nucleic acid molecule encoding the antigen; one or both of a PPAR ligand and an RxR ligand; and a pharmaceutically suitable carrier. The pharmaceutical composition can optionally include a mitogen or other additives. Also disclosed are methods of inducing B cell differentiation and promoting an immune response against an antigen.