(S)-3-(4-Benzyloxy-phenyl)-2-[bis-(4-tert-butyl-benzyl)-amino]-N-(2-piperidin-1-yl-ethyl)-propionamide | 256653-18-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-3-(4-Benzyloxy-phenyl)-2-[bis-(4-tert-butyl-benzyl)-amino]-N-(2-piperidin-1-yl-ethyl)-propionamide
• 英文别名: (2S)-2-[bis[(4-tert-butylphenyl)methyl]amino]-3-(4-phenylmethoxyphenyl)-N-(2-piperidin-1-ylethyl)propanamide
• CAS: 256653-18-6
• 化学式: C₄₅H₅₉N₃O₂
• 分子量: 673.982
• InChiKey: BFHSTXSKEUCPQH-WBCKFURZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.3
• 重原子数：
  50
• 可旋转键数：
  16
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  44.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• US6180677B1
  申请人：——

  公开号：US6180677B1

  公开（公告）日：2001-01-30
• US6323243B1
  申请人：——

  公开号：US6323243B1

  公开（公告）日：2001-11-27
• [EN] TYROSINE-DERIVED COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS<br/>[FR] COMPOSES DERIVES DE LA TYROSINE UTILISES COMME ANTAGONISTES DES CANAUX CALCIQUES
  申请人：WARNER LAMBERT CO

  公开号：WO2000006535A1

  公开（公告）日：2000-02-10

  The present invention provides compounds that block calcium channels and have Formula (I), and pharmaceutically acceptable salts, esters, and pro-drugs thereof, wherein R?1 and R2¿ are independently H, phenylcyclopentylcarbonyl, C¿1?-C7 alkyl, cyclohexylmethyl, benzyl, C1-C5 alkylbenzyl, or C1-C5 alkoxybenzyl, A is -C(O)- or -CH2-; R?3¿ is H or -CH¿3?; R?4 is C¿1-C4 alkyl or piperidin-1-ylethyl; R5 is phenyl-(CH¿2?)n-, C1-C4 alkylphenyl-(CH2)n-, or halophenyl-(CH2)n-; and n is 1 or 2. The present invention also provides pharmaceutical compositions containing the compounds of Formula I and methods of using them to treat stroke, cerebral ischemia, head trauma, and epilepsy.