2-amino-N-[(2R)-3-(1H-indol-3-yl)-1-oxo-1-[[1-(2-oxo-1-phenyl-2-pyrrolidin-1-ylethyl)imidazol-4-yl]amino]propan-2-yl]-2-methylpropanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-amino-N-[(2R)-3-(1H-indol-3-yl)-1-oxo-1-[[1-(2-oxo-1-phenyl-2-pyrrolidin-1-ylethyl)imidazol-4-yl]amino]propan-2-yl]-2-methylpropanamide
• 化学式: C₃₀H₃₅N₇O₃
• 分子量: 541.6
• InChiKey: YWDIZSKDAFCFGS-RMVMEJTISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  40
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  138
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Growth hormone secretagogues
  申请人：Dodge Alan Jeffrey

  公开号：US20050143318A1

  公开（公告）日：2005-06-30

  What is disclosed are growth hormone secretagogues, and their uses, of formula (I) wherein R1 is C 6 H 5 CH 2 OCH 2 —, C 6 H 5 (CH 2 ) 3 — or indol-3-ylmethyl; Y is pyrrolidin-1-yl, 4-C 1 -C 6 alkylpiperidin-1-yl or NR2R2; R2 are each independently a C 1 to C 6 alkyl; R3 is 2-napthyl or phenyl para-substituted by W; W is H, F, CF 3 , C 1 -C 6 alkoxy or phenyl; and R4 is H or CH 3 , or a pharmaceutically acceptable salt or solvate thereof.

  所透露的是生长激素分泌素及其使用方法，其化学式为(I)，其中R1为C6H5CH2OCH2—、C6H5(CH2)3—或indol-3-ylmethyl；Y为pyrrolidin-1-yl、4-C1-C6alkylpiperidin-1-yl或NR2R2；R2各自独立地为C1到C6烷基；R3为2-napthyl或苯基，对位取代为W；W为H、F、CF3、C1-C6烷氧基或苯基；R4为H或CH3，或其药学上可接受的盐或溶剂。
• Growth Hormone secretagogues
  申请人：——

  公开号：US20040122234A1

  公开（公告）日：2004-06-24

  This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

  本发明涉及一种新型化合物，该化合物在哺乳动物内调节内源性生长激素水平方面具有用途。本发明还涉及用于合成所述化合物的新型中间体，以及用于这些合成的新型过程。还包括包括给予所述化合物的治疗哺乳动物的方法。
• Congestive heart failure treatment
  申请人：ELI LILLY AND COMPANY

  公开号：EP0898963A2

  公开（公告）日：1999-03-03

  The invention provides methods for the modulation of cardiac function by the administration of a growth hormone secretagogue, which results in an increase in the levels of endogenous growth hormone. Also provided are methods for the treatment of congestive heart failure by the administration of a growth hormone secretagogue. Further provided are methods for the treatment of congestive heart failure by the administration of a growth hormone secretagogue in combination with a growth hormone releasing hormone, or in combination with an antihypertensive agent, diuretic, or other suitable agents.

  本发明提供了通过服用生长激素促泌剂来调节心脏功能的方法，这种促泌剂可提高内源性生长激素的水平。本发明还提供了通过服用生长激素分泌物治疗充血性心力衰竭的方法。此外，还提供了通过服用生长激素促泌剂与生长激素释放激素联合，或与降压药、利尿剂或其他合适的药物联合，治疗充血性心力衰竭的方法。
• US6329342B1
  申请人：——

  公开号：US6329342B1

  公开（公告）日：2001-12-11
• US6828331B1
  申请人：——

  公开号：US6828331B1

  公开（公告）日：2004-12-07