Methacryloxytrimethyl-ammonium chloride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Methacryloxytrimethyl-ammonium chloride
• 英文别名: trimethyl(2-methylprop-2-enoyloxy)azanium;chloride
• 化学式: C7H14ClNO2
• 分子量: 179.64
• InChiKey: NEQZXUBZTZDVAF-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.27
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• 1,3,5-Triazines for Treatment of Viral Diseases
  申请人：Daifuku Richard

  公开号：US20070207973A1

  公开（公告）日：2007-09-06

  The present invention provides compounds and methods for treatment of viral diseases and cancer.

  本发明提供了用于治疗病毒性疾病和癌症的化合物和方法。
• 1,3,5-Triazines for treatment of viral diseases
  申请人：Koronis Pharmaceuticals, Inc.

  公开号：US20040127436A1

  公开（公告）日：2004-07-01

  The present invention provides compounds and methods for treatment of viral diseases and cancer.

  本发明提供了用于治疗病毒性疾病和癌症的化合物和方法。
• Novel methods of imaging and treatment with targeted compositions
  申请人：——

  公开号：US20030157025A1

  公开（公告）日：2003-08-21

  Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination with a targeting ligand, and scanning the patient using ultrasound. The scanning may comprise exposing the patient to a first type of ultrasound energy and then interrogating the patient using a second type of ultrasound energy. The targeting ligand preferably targets tissues, cells or receptors, including myocardial cells, endothelial cells, epithelial cells, tumor cells and the glycoprotein GPIIbIIIa receptor. The methods may be used to detect a thrombus, enhancement of an old or echogenic thrombus, low concentrations of vesicles and vesicles targeted to tissues, cells or receptors.

  新型超声波方法包括向患者施加含有脂质、蛋白质或聚合物的气囊组成的有针对性的气囊组合物，该气囊包含一种气体，并与一个靶向配体结合，然后使用超声波扫描患者。扫描可能包括将患者暴露于第一种超声波能量，然后使用第二种超声波能量对患者进行询问。靶向配体首选靶向组织、细胞或受体，包括心肌细胞、内皮细胞、上皮细胞、肿瘤细胞和糖蛋白GPIIbIIIa受体。该方法可用于检测血栓、旧血栓或回声增强、低浓度气囊和靶向组织、细胞或受体的气囊。
• 1,3,5-TRIAZINES FOR TREATMENT OF VIRAL DISEASES
  申请人：Daifuku Richard

  公开号：US20070142310A1

  公开（公告）日：2007-06-21

  The present invention provides compounds and methods for treatment of viral diseases and cancer.

  本发明提供了用于治疗病毒性疾病和癌症的化合物和方法。
• [EN] CHEMILUMINESCENT DYES AND DYE-STAINED PARTICLES<br/>[FR] COLORANTS CHIMILUMINESCENTS ET PARTICULES COLORÉES PAR UN COLORANT
  申请人：UNIV NOTRE DAME DU LAC

  公开号：WO2011087521A1

  公开（公告）日：2011-07-21

  Chemiluminescent compounds that can be activated by reaction with chemical or photochemical sources of singlet oxygen are provided. At certain temperatures, such as from approximately 15 to 60°C, the compounds slowly return to their deactivated state by emitting visible and/or infrared light that is observable with various types of light detectors. Suitable conjugates of these compounds, or small particles containing these compounds, may be used for chemiluminescence imaging and sensing technologies. In particular, embodiments provide optical molecular imaging using novel squaraine rotaxane endoperoxides (SREPs) and squaraine catenane endoperoxides (SCEPs), interlocked fluorescent and chemiluminescent dye molecules that have a squaraine chromophore encapsulated inside a macrocycle endoperoxide. The dyes may be stored at low temperature, such as below 0°C, but, upon warming above 15°C, such as to body temperature, they undergo a unimolecular cycloreversion reaction that releases singlet oxygen and emits visible or near-infrared light that can pass through living tissue. The chemiluminescent signal is detectable with inherently high contrast because there is negligible background emission.

  提供了可以通过与化学或光化学单线态氧源反应而激活的化学发光化合物。在某些温度下，例如从大约15到60°C，这些化合物通过发射可见光和/或红外光缓慢地返回到它们的失活状态，这可以通过各种类型的光探测器观察到。这些化合物的合适共轭物或含有这些化合物的小颗粒可用于化学发光成像和传感技术。特别地，实施例提供使用新型方酸亚胺轮烷内过氧化物（SREPs）和方酸亚胺猫烷内过氧化物（SCEPs）进行光学分子成像，这是一种被锁定的荧光和化学发光染料分子，其具有被封装在大环内过氧化物中的方酸亚胺色团。这些染料可以储存在低温下，例如低于0°C，但是当升温到15°C以上，例如到体温时，它们会经历一种单分子环反应，释放单线态氧并发射可穿过活体组织的可见光或近红外光。化学发光信号是可检测的，因为背景发射很小，具有固有的高对比度。