1-[(3R,4S)-1-(3,4-dimethylphenoxy)-4-hydroxypentan-3-yl]imidazole-4-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-[(3R,4S)-1-(3,4-dimethylphenoxy)-4-hydroxypentan-3-yl]imidazole-4-carboxamide
• 化学式: C₁₇H₂₃N₃O₃
• 分子量: 317.4
• InChiKey: GQGRWPDCYSRISG-XJKSGUPXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  90.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Imidazole derivatives as adenosine deaminase inhibitors
  申请人：——

  公开号：US20040236114A1

  公开（公告）日：2004-11-25

  Imidazole compounds having adenosine deaminase inhibitory activity represented by the formula (I) wherein R1 is aryl or heterocyclic group which is optionally substituted with substituent(s); R 2 is lower alkyl; R 3 is hydroxy or protected hydroxy; -A- is lower alkylene; and —X—is —O— or —S—; provided that when then R1 is aryl which is substituted with substituent(s), or heterocyclic group which is optionally substituted with substituent(s), its prodrug, or their salt. The compounds are useful for treating and/or preventing diseases for which adenosine is effective. 1

  具有腺苷脱氨酶抑制活性的咪唑化合物，其化学式表示为（I），其中R1是芳基或杂环基，可选地带有取代基；R2是较低的烷基；R3是羟基或保护羟基；-A-是较低的烷基；而—X—是—O—或—S—；但当R1是带有取代基的芳基或可选带有取代基的杂环基时，其前药或其盐。这些化合物可用于治疗和/或预防腺苷在其中有效的疾病。
• US7064144B2
  申请人：——

  公开号：US7064144B2

  公开（公告）日：2006-06-20