3-[1-(1H-imidazol-5-yl)ethyl]-2,3-dihydro-1H-inden-5-ol;hydrochloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 3-[1-(1H-imidazol-5-yl)ethyl]-2,3-dihydro-1H-inden-5-ol;hydrochloride
• 化学式: C14H17ClN2O
• 分子量: 264.75
• InChiKey: AMPOOHDFJIOGBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.37
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  48.9
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• METHOD OF ADMISTERING AN IMIDAZOLE DERIVATIVE TO OBTAIN ANALGESIA
  申请人：ORION CORPORATION

  公开号：EP1196168A2

  公开（公告）日：2002-04-17
• [EN] METHOD OF ADMISTERING AN IMIDAZOLE DERIVATIVE TO OBTAIN ANALGESIA<br/>[FR] PROCEDE D'ADMINISTRATION D'UN DERIVE D'IMIDAZOLE POUR OBTENIR UNE ANALGESIE
  申请人：ORION CORP

  公开号：WO2001000192A2

  公开（公告）日：2001-01-04

  The present invention relates to a method for obtaining analgesia by administering 3-[1-(1H-imidazol-4-yl)-ethyl]-indan-5-ol, its enantiomer or a pharmaceutically acceptable ester or salt thereof to a mammal intraspinally. 3-[1-(1H-imidazol-4-yl)-ethyl]-indan-5-ol, its enantiomer or a pharmaceutically acceptable ester or salt thereof can be administered intraspinally to a mammal obtaining analgesia without side-effects, such as sedation. The present invention also relates to a method for using the drug as an adjunct to anaesthesia by administering it intraspinally.